II. Indications

  1. See Menactra (MCV4) which is preferred due to higher immunogenicity

III. Mechanism

  1. Quadrivalent Meningococcal Polysaccharide Vaccine
  2. Covers strains A, C, W-135, and Y (does not contain B serotype)
    1. Covers same strains as Menactra
    2. See Menactra for further explanation
  3. Cost: $100 (similar to Menactra)
  4. Storage: 35 to 46 F (2 to 8 C), Same as Menactra

IV. Dose: Menomune

  1. Adult: 0.5 ml SC every 3 years
  2. Intramuscular may be preferred over subcutaneous route
    1. Intramuscular Injection reduces adverse effects
      1. Local erythema (11% for IM, 32% for SC)
      2. Headache (3% for IM and 12% for SC)
    2. Intramuscular has same efficacy as subcutaneous route

V. Efficacy

  1. Like Menactra, Menomune has a high seroconversion rate (98%-100%)
  2. However Menomune duration is much shorter
    1. Menomune duration lasts 3 years in school age children and less in infants

VI. Precautions: Safety

  1. Contains Thimerosal
  2. Approved for all ages
  3. Safe in Human Immunodeficiency Virus (HIV)
    1. See Immunization in HIV

VII. Adverse effects

  1. Serious adverse events are uncommon (<1.3%)
  2. Headache
  3. Fever (in up to 3% of children)
  4. Local reactions (more common with Menactra)

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Ontology: Menomune (C0244512)

Concepts Pharmacologic Substance (T121) , Immunologic Factor (T129)
MSH D022401
French Menomune
English menomune, Sanofi Pasteur Brand of Meningococcal Polysaccharide Vaccine, Menomune