II. Indications

  1. Primary Immunization series
  2. Travel to endemic area
    1. Asia
    2. Africa

III. Pathophysiology

  1. Reasoning in switch from OPV to EIPV
    1. Rare risk of poliomyelitis
    2. See Oral Polio Vaccine complications below
  2. All EIPV would result in no cases of polio
    1. But decreased mucosal (GI, mucus membrane) Immunity
    2. Chance for exposure from cases from Endemic areas
      1. China
      2. India

IV. Contraindications to OPV

  1. Immunodeficiency disorders
  2. Household contacts of immunodeficient person
  3. Pregnancy
  4. Hypersensitivity to Vaccine
  5. Anaphylactic reaction to neomycin or Streptomycin

V. Dose

  1. Adults: EIPV 0.5 ml SC

VI. Schedule (New recommended schedule)

  1. Recent modification recommends EIPV for all 4 doses
    1. Dose 1: Age 2 months
    2. Dose 2: Age 4 months
    3. Dose 3: Age 6 to 18 months
    4. Dose 4: Age 4 to 6 years

VII. Precaution

  1. EIPV is Safe in HIV and Pregnancy
  2. Avoid OPV in HIV and Pregnancy

VIII. Complications: Oral Polio Vaccine (OPV)

  1. Cases per year Poliomyelitis associated with OPV: 8
    1. One case per 2 million doses
    2. EIPV results in no cases of poliomyelitis

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Ontology: Oral Poliovirus Vaccine (C0032375)

Definition (HL7V3.0) <p>poliovirus vaccine, live, oral</p>
Definition (NCI) A vaccine that contains live attenuated polio virus. It is administered orally as polio prophylaxis in many areas of the world, but not in the U.S. since 2000.
Definition (MSH) A live vaccine containing attenuated poliovirus, types I, II, and III, grown in monkey kidney cell tissue culture, used for routine immunization of children against polio. This vaccine induces long-lasting intestinal and humoral immunity. Killed vaccine induces only humoral immunity. Oral poliovirus vaccine should not be administered to immunocompromised individuals or their household contacts. (Dorland, 28th ed)
Concepts Organic Chemical (T109) , Immunologic Factor (T129) , Pharmacologic Substance (T121)
MSH D011055
SnomedCT 125690004, 268590009, 111164008, 396436004
HL7 02, 2
English Poliovirus Vaccine, Oral, Sabin Vaccine, Vaccine, Oral Poliovirus, Vaccine, Sabin, Oral Poliovirus Vaccine, Poliovirus Vaccine, Oral [Chemical/Ingredient], oral poliomyelitis vaccine, opv, sabin vaccine, oral polio vaccine (OPV), topv, Oral Polio Vaccine, poliovirus vaccine, live, oral, Oral polio vaccine, Poliomyelitis vaccine, Oral, OPV, Pol/Vac (oral), Sabin vaccine, TOPV, Poliovirus Vaccine Live Oral
Swedish Poliovaccin, oralt
Czech poliovirová vakcína orální
Spanish Vacuna Sabin, vacuna Sabin, Vacuna Oral contra Poliovirus, vacuna de Sabin, Vacuna Antipolio Oral
Finnish Oraalinen poliovirusrokote
Italian Vaccino di Sabin, Vaccino poliomielitico orale
Russian SEIBINA VAKTSINA, VAKTSINA PROTIV POLIOMIELITA ORAL'NAIA, SABINA VAKTSINA, ВАКЦИНА ПРОТИВ ПОЛИОМИЕЛИТА ОРАЛЬНАЯ, САБИНА ВАКЦИНА, СЕЙБИНА ВАКЦИНА
Polish Szczepionka przeciw poliomyelitis doustna, Szczepionka Sabina
Japanese ポリオウイルス経口生ワクチン, ポリオウイルス経口ワクチン, 経口生ワクチン-ポリオウイルス, 経口ポリオワクチン, 経口3価ワクチン-ポリオウイルス, ポリオウイルス経口生3価ワクチン, 経口生3価ワクチン-ポリオウイルス, 経口ワクチン-ポリオウイルス, ポリオウイルス経口3価ワクチン, セービンワクチン, 経口ポリオウイルスワクチン, ポリオウイルスワクチン-経口, ポリオワクチン-経口, ワクチン-ポリオ-経口
French Sabin, vaccin, Vaccin antipoliomyélitique buccal, Vaccin antipoliomyélitique Sabin
German Polio-Lebendimpfstoff, Poliomyelitis-Vakzine, orale, Sabin-Impfstoff, Sabin-Vakzine
Portuguese Vacina Antipólio Oral, Vacina Sabin

Ontology: Poliovirus Vaccine, Inactivated (C0718003)

Definition (HL7V3.0) <p>poliovirus vaccine, inactivated</p>
Definition (NCI) A vaccine consisting of inactivated poliovirus (IPV) types 1,2 and 3, with active immunizing activity against poliomyelitis. Upon intramuscular vaccination, inactivated poliovirus vaccine (IPV) activates the immune system to develop antibodies against polioviruses.
Definition (MSH) A suspension of formalin-inactivated poliovirus grown in monkey kidney cell tissue culture and used to prevent POLIOMYELITIS.
Concepts Pharmacologic Substance (T121) , Immunologic Factor (T129)
MSH D011054
SnomedCT 125688000, 396435000
CPT 90713
HL7 10
LNC LP91385-2
English Inactivated poliomyelitis vac, diphtheria + tetanus toxoid + inactivated polio vaccine (IPV) (medication), diphtheria + tetanus toxoid + inactivated polio vaccine (IPV), diphtheria + tetanus toxoid + poliovirus vaccine, IPV, polio vaccine, inactivated (monkey kidney), poliovirus vaccine, inactivated, poliomyelitis vaccine (inactivated), Poliovirus Vaccine, Inactivated [Chemical/Ingredient], inactivated poliovirus vaccine, IPV, inactivated poliovirus vaccine, IPV (medication), inactivated polio vaccine, inactivated poliomyelitis vaccine, Inactivated Poliovirus Vaccine, Vaccine, Inactivated Poliovirus, poliomyelitis vaccine,killed, IPV, Inactivated poliomyelitis vaccine, Pol/Vac (inact), Inactivated poliovirus vaccine (product), Inactivated poliovirus vaccine (substance), Inactivated poliovirus vaccine, Poliovirus Vaccine, Inactivated, POLIOVIRUS VACCINE INACTIVATED, Poliovirus Vaccine Inactivated
Swedish Poliovaccin, avdödat
Czech poliovirová vakcína inaktivovaná
Finnish Inaktivoitu poliovirusrokote
Russian SOLKA VAKTSINA, VAKTSINA PROTIV POLIOMIELITA INAKTIVIROVANNAIA, INAKTIVIROVANNAIA VAKTSINA SOLKA, ВАКЦИНА ПРОТИВ ПОЛИОМИЕЛИТА ИНАКТИВИРОВАННАЯ, ИНАКТИВИРОВАННАЯ ВАКЦИНА СОЛКА, СОЛКА ВАКЦИНА
Polish Szczepionka przeciw poliomyelitis inaktywowana, Szczepionka Salka
Spanish Vacuna Antipoliomielítica de Virus Inactivados, Vacuna Inactivada contra Poliovirus, IPV, Vacuna Inactivada del Virus de la Poliomielitis, vacuna antipoliomielítica a virus inactivados (sustancia), vacuna antipoliomielítica a virus inactivados, vacuna antipoliomielítica de virus inactivados (producto), vacuna antipoliomielítica de virus inactivados (sustancia), vacuna antipoliomielítica de virus inactivados, Vacuna Antipolio de Virus Inactivados
Portuguese IPV, Vacina Inativada Contra Pólio, Vacina Inativada contra Poliovirus, Vacina de Poliovirus Inativado, Vacina Antipólio de Vírus Inativado
French Vaccin antipoliomyélitique inactivé, Vaccin antipoliomyélitique injectable, Vaccin inactivé contre la poliomyélite
German Poliomyelitisvirus-Vakzine, inaktivierte
Italian Vaccino poliomielitico inattivato