II. Causes: Classic Exanthems (historical order of first identified)

  1. First: Rubeola (Measles)
  2. Second: Scarlet Fever (Streptococcus Pyogenes)
  3. Third: Rubella (German Measles)
  4. Fourth: Dukes' Disease (Coxsackievirus or Echovirus)
  5. Fifth: Fifth Disease (Erythema Infectiosum, Parvovirus)
  6. Sixth: Exanthem Subitum (Roseola Infantum, HH6, HH7)

III. Causes: Distribution of Febrile Eruption

  1. Central Eruptions (starts with head and neck)
    1. Viral Exanthem
      1. Rubeola
      2. Rubella
      3. Parvovirus B19 (Erythema Infectiosum)
      4. Roseola Infantum
    2. Lyme Disease (Erythema Migrans)
    3. Drug eruption
  2. Peripheral Eruptions (starts on distal extremities)
    1. Erythema Multiforme
    2. Secondary Syphilis
    3. Meningococcemia
    4. Rocky Mountain Spotted Fever
    5. Dengue Fever

IV. Causes: Petechial Eruptions in the Febrile Patient

  1. Common and Urgent Causes
    1. Meningococcemia
    2. Rocky Mountain Spotted Fever
  2. Viral Causes
    1. Coxsackievirus A9
    2. Echovirus 9
    3. Epstein-Barr Virus
    4. Cytomegalovirus
    5. Atypical Measles
    6. Viral Hemorrhagic Fever
      1. Arbovirus Infection
      2. Arenavirus Infection
  3. Other Causes
    1. Disseminated Gonococcus
    2. Staphylococcemia
    3. Thrombotic Thrombocytopenic Purpura

V. Causes: Diffuse Erythema and Desquamation in the Febrile Patient

  1. Most Common
    1. Scarlet Fever
    2. Kawasaki's Disease
    3. Toxic Shock Syndrome
    4. Scalded Skin Syndrome
  2. Less Common
    1. Ehrlichiosis
    2. Streptococcus viridans bacteremia
    3. Enteroviral infection
    4. Toxic Epidermal Necrolysis
    5. Graft-versus-host reaction
    6. Erythroderma
    7. Generalized Pustular Psoriasis (von Zumbusch)

VI. Causes: Vesiculobullous Eruptions in the Febrile Patient

  1. Common
    1. Varicella Zoster Virus (Chicken Pox)
    2. Herpes Zoster (Shingles)
    3. Hand Foot and Mouth Disease
  2. Less common
    1. Staphylococcal Bacteremia
    2. Gonococcemia
  3. Immunocompromised Patient Causes
    1. Disseminated Herpes Simplex Virus
    2. Vibrio vulnificus (seafood exposure)
    3. Rickettsia akari

VII. Causes: Nodular Eruptions in the Febrile Patient

  1. Erythema Nodosum
  2. Disseminated fungal infection (Immunocompromised)
    1. Disseminated Candidiasis
    2. Cryptococcosis
    3. Blastomycosis
    4. Histoplasmosis
    5. Coccidioidomycosis
    6. Sporotrichosis
  3. Other rare causes
    1. Nocardia
    2. Pseudomonas
    3. Mycobacterium species

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Ontology: Viral exanthem (C0153062)

Concepts Disease or Syndrome (T047)
ICD9 057.9
ICD10 B09
SnomedCT 186504007, 421512008, 266188005, 186586006, 154319002, 49882001
English Viral diseases + exanthem NOS, Viral diseases with exanthemata NOS, Nonspecific viral rash, Nonspecific exanthematous viral infection (disorder), Nonspecific exanthematous viral infection, Nonspecific viral exanthem, Viral dis char by exanthem, viral exanthem (diagnosis), viral exanthem, Viral exanthema, unspecified, Viral exanthemata, unspecified, Non-specific viral rash, Viral rash NOS, Viral exanthemata NOS, non-specific viral rash, nonspecific viral rash, viral rash, Exanthema;viral, exanthems viral, rash viral, Rash;viral, exanthem viral, viral exanthemata, Viral exanthema NOS, Exanthem - viral, Viral diseases with exanthemata NOS (disorder), Viral exanthem, Viral exanthemata, Viral disease characterised by exanthem, Viral disease characterized by exanthem, Viral rash, Viral disease characterized by exanthem (disorder), Viral exanthem (disorder), exanthema; virus, virus; exanthem, Viral exanthem, unspecified, viral exanthema
Italian Esantema virale, Esantemi virali non specificati, Esantema virale NAS, Esantema virale non specifico
Spanish exantema viral inespecífico, exantema viral no específico, exantema viral inespecífico (trastorno), Exantemas víricos no especificados, Exantema vírico, Exantema vírico inespecífico, Exantema vírico no especificado, Erupción vírica NEOM, exantema virósico, exantema vírico, exantema vírico inespecífico, infección vírica exantematosa inespecífica, infección viral exantematosa inespecífica, enfermedad vírica caracterizada por exantema, enfermedades virales con exantema, SAI, enfermedades virales con exantema, SAI (trastorno), enfermedad viral caracterizada por exantema (trastorno), enfermedad viral caracterizada por exantema, enfermedad virosa caracterizada por exantema (trastorno), enfermedad virosa caracterizada por exantema, exantema viral (trastorno), exantema viral, Erupción vírica
Dutch niet-specifieke virale rash, virale exanthemen, niet-gespecificeerd, viraal exantheem, niet-gespecificeerd, virale rash NAO, viraal exantheem, exantheem; virus, virus; exantheem, virale rash
French Exanthème viral, non précisé, Exanthème viral, Eruption virale SAI, Rash viral non précisé, Rash viral
German virales Exanthem, nichtspezifischer viraler Hautausschlag, virales Exanthem, unspezifisch, virusbedingter Ausschlag NNB, virale Exantheme, unspezifisch, viraler Hautausschlag
Portuguese Erupção cutânea viral NE, Erupção cutânea vírica inespecífica, Exantema vírico, Exantema vírico NE, Exantemas víricos NE, Erupção cutânea viral
Japanese 非特異的ウイルス性発疹, ウイルス性発疹, ウイルス性発疹、詳細不明, ウイルス性発疹NOS, ウイルスセイホッシン, ウイルスセイハッシンショウサイフメイ, ウイルスセイハッシン, ヒトクイテキウイルスセイホッシン, ウイルスセイホッシンショウサイフメイ, ヒトクイテキウイルスセイハッシン, ウイルスセイハッシンNOS, ウイルスセイホッシンNOS
Czech Virový exantém, Virový exantém NOS, Virový exantém, blíže neurčený, Virové exantémy, blíže neurčené, Nespecifický virový exantém
Hungarian Viralis exanthema, nem meghatározott, vírusos kiütés k.m.n., Viralis nem specifikus kiütés, Vírusos kiütés, nem meghatározott, Viralis kiütés, vírusos kiütés

Ontology: fever with rash (C0847014)

Concepts Sign or Symptom (T184)
English fever rash, fevers rash, Pyrexia;with rash, rash fever, fever with rash, rash with fever, pyrexia with rash