II. Pathophysiology

  1. Onset 2 to 12 weeks after starting Antiretroviral therapy for HIV (onset up to years after starting CART in rare cases)
  2. Recovering immune system and rising CD4 Counts respond to latent infections and malignancies

III. Findings

  1. Fever
  2. Lymphadenopathy
  3. Symptoms or signs related to underlying infection or malignancy

IV. Risk Factors

  1. Low starting CD4 Count

V. Differential Diagnosis

  1. Antiretroviral therapy related Drug Reaction

VI. Management

  1. Treat underlying infection or malignancy
  2. Observation and supportive care
  3. Consult with HIV specialist
    1. In unusual cases, Antiretroviral therapy may need to be held

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Ontology: Immune Reconstitution Inflammatory Syndrome (C1619738)

Definition (MSH) Exuberant inflammatory response towards previously undiagnosed or incubating opportunistic pathogens. It is frequently seen in AIDS patients following HAART.
Concepts Disease or Syndrome (T047)
MSH D054019
English Immune Restoration Syndrome, Restoration Syndrome, Immune, Syndrome, Immune Restoration, Reconstitution Disease, Immune, Reconstitution Syndrome, Immune, Syndrome, Immune Reconstitution, Immune Reconstitution Syndromes, Reconstitution Syndromes, Immune, Syndromes, Immune Reconstitution, Immune Reconstitution Disease, Disease, Immune Reconstitution, Immune Reconstitution Syndrome, Immune Reconstitution Inflammatory Syndrome, Immune Reconstitution Inflammatory Syndrome [Disease/Finding], Immune reconstitution inflammatory syndrome
Portuguese Síndrome da Restauração Imune, Doença da Reconstituição Imune, Síndrome de reconstituição imunológica inflamatória, Síndrome Inflamatória da Reconstituição Imune, Síndrome da Reconstituição Imunológica, Síndrome da Reconstituição Inflamatória Imune, Síndrome Inflamatória da Reconstituição Imunológica, Síndrome de Reconstituição Imune
Spanish Síndrome Inflamatorio de Reconstitución Inmune, Enfermedad de Reconstitución Inmune, Síndrome de Restauración Inmune, Síndrome inflamatorio de reconstitución inmune
Finnish Elpyvän immuniteetin tulehdusoireyhtymä
French Syndrome de restauration immunitaire, SRI (Syndrome de Restauration Immunitaire), Syndrome inflammatoire de restauration immunitaire
German Immunrekonstitutionssyndrom, Immunrekonstitutionelles inflammatorisches Syndrom, IRS, IRIS, Immunrekonstitutions-Syndrom
Italian Malattia da immunoricostituzione, Sindrome infiammatoria da immunoricostituzione, Sindrome da immunoricostituzione, Sindrome infiammatoria da recupero delle difese immunitarie
Russian ИММУННОЙ РЕКОНСТИТУЦИИ ВОСПАЛИТЕЛЬНЫЙ СИНДРОМ, SINDROM IMMUNNOGO VOSSTANOVLENIIA, BOLEZNI REKONSTITUTSII IMMUNNOI SISTEMY, БОЛЕЗНИ РЕКОНСТИТУЦИИ ИММУННОЙ СИСТЕМЫ, IMMUNNOI REKONSTITUTSII VOSPALITEL'NYI SINDROM, СИНДРОМ ИММУННОГО ВОССТАНОВЛЕНИЯ
Japanese 免疫再構築症候群, 免疫再構築炎症反応症候群, メンエキサイコウチクエンショウハンノウショウコウグン
Czech imunorestituční zánětlivý syndrom, Zánětový syndrom imunní rekonstituce
Swedish Immunrekonstitutionssyndrom
Polish Zespół odnowy immunologicznej, IRIS, Choroba odbudowy immunologicznej, Zapalny zespół rekonstrukcji immunologicznej, Zespół rekonstrukcji immunologicznej, Zespół odbudowy immunologicznej, Zespół IRIS
Dutch immuunreconstitutie-ontstekingssyndroom
Hungarian Immun-rekonstitúciós gyulladásos syndroma
Norwegian Inflammatorisk immunrekonstitusjonssyndrom, IRS, Immunrekonstitusjonssyndrom, IRIS, Immunrekonstitusjonssykdom