II. Class

  1. Anti-retroviral agent
  2. Entry Inhibitor

III. Mechanism

  1. Blocks HIV to chemokine (CCR5 - R5) receptor binding on CD4 cells
  2. Since only effective on R5 cells - requires R5 tropism test prior to initiating Maraviroc

IV. Indications

  1. Anti-retroviral naive patients
  2. Anti-retroviral experienced patients

V. Adverse Effects

  1. Well tolerated overall
  2. Fever
  3. Upper respiratory symptoms (e.g. cough, Bronchitis)
  4. Abdominal Pain
  5. Rash
  6. Orthostatic Hypotension
  7. Myalgia
  8. Hepatotoxicity (may be associated with rash and Eosinophilia)
  9. Increased Myocardial Infarction risk

VI. Monitoring

  1. Requires R5 tropism test prior to initiating Maraviroc

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Cost: Medications

selzentry (on 1/28/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
SELZENTRY 150 MG TABLET $20.78 each
SELZENTRY 300 MG TABLET $20.78 each