II. Dose

  1. Streptokinase 1.5 million units over 60 minutes
  2. Premedication
    1. Hydrocortisone 100 mg IV
    2. Diphenhydramine 25 mg IV

III. Contraindications: Conditions in which streptococcal Antibody is more likely to be present (risk of severe Allergic Reaction)

  1. Prior exposure to Streptokinase
  2. Recent streptococcal infection

IV. Benefits

  1. Cost: $200
  2. Lasts longer than T-PA (duration 24 hours)
  3. Less bleeding risk
    1. Probably less risk than T-PA in over age 75

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Ontology: Streptokinase (C0038418)

Definition (MSH) Streptococcal fibrinolysin . An enzyme produced by hemolytic streptococci. It hydrolyzes amide linkages and serves as an activator of plasminogen. It is used in thrombolytic therapy and is used also in mixtures with streptodornase (STREPTODORNASE AND STREPTOKINASE). EC 3.4.-.
Definition (CSP) nonEC; enzyme elaborated by hemolytic streptococci which produces fibrinolysis by activating plasminogen to plasmin; it is used as a thrombolytic agent.
Concepts Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSH D013300
SnomedCT 319810009, 395889004, 20847002
LNC LP16489-4, MTHU021627
English Streptokinase, streptokinase, streptokinase (medication), Streptokinase [Chemical/Ingredient], SK - Streptokinase, Streptokinase (product), Streptokinase (substance), Streptokinase preparation (substance), STREPTOKINASE, Streptokinase preparation, Streptokinase agent (substance), Streptokinase agent
Spanish preparado de estreptoquinasa (sustancia), preparado de estreptoquinasa, estreptoquinasa (producto), estreptocinasa, estreptoquinasa, estreptocinasa (sustancia), estreptokinasa, estreptoquinasa (sustancia), estreptocinasa (producto), Estreptocinasa, estreptokinasa (producto), estreptokinasa (sustancia), Estreptoquinasa
Swedish Streptokinas
Czech streptokinasa
Finnish Streptokinaasi
Russian NEITRAL'NAIA PROTEINAZA STAPHYLOCOCCUS AUREUS, STREPTOKINAZA, STREPTAZA, НЕЙТРАЛЬНАЯ ПРОТЕИНАЗА STAPHYLOCOCCUS AUREUS, СТРЕПТАЗА, СТРЕПТОКИНАЗА
Japanese ストレプトキナーゼ
Croatian STREPTOKINAZA
Polish Streptokinaza
Norwegian Not Translated[Streptokinase]
French Streptokinase
German Streptokinase
Italian Streptochinasi
Portuguese Estreptoquinase