II. Indication

  1. Leukemia management
  2. Bone Marrow Suppression following high dose chemo

III. Advantages: Compared with Bone Marrow Transplant

  1. More effective than Bone Marrow Transplant
  2. Much easier to harvest
    1. Identify CD34 antigen via Monoclonal Antibody
  3. Small volume of peripheral stem cells effective
  4. Greater disease free survival than Bone Marrow
  5. Shorter hospitalization (2 weeks rather than 3 weeks)
  6. Much less costly

IV. Management: Surveillance of survivors treated with Hematopoietic Stem Cell Transplantation

  1. Complete Blood Count with differential
    1. Every 1-2 months for 3 years THEN
    2. Every 3-6 months for up to 5 years THEN
    3. Annually
  2. Testing at one year following Stem Cell Transplantation
    1. CD4 Cell Count
    2. Immunoglobulin level
    3. Bone density
    4. Ophthalmic exam
  3. Annual lab testing
    1. Comprehensive metabolic panel
      1. Includes serum electrolytes, Serum Glucose, Serum Creatinine, Blood Urea Nitrogen and Liver Function Tests
    2. Thyroid Stimulating Hormone
    3. Urinalysis and Urine Microalbumin
    4. Serum Ferritin
    5. Vitamin D
    6. Hemoglobin A1C
    7. Serum Testosterone in males
    8. Follicle Stimulating Hormone (FSH) and Luteinizing hormone (LH) in females
  4. Routine Health Maintenance
    1. Dental exams at least annually
    2. Routine cancer screening
    3. Immunizations
  5. Pulmonary Function Test indications
    1. If abnormal prior to treatment

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Ontology: Hemopoietic stem cell transplant (C0472699)

Definition (NCI) A therapeutic procedure that involves the transplantation of hematopoietic stem cells from a donor to a patient with a myeloid or lymphocytic malignancy.
Definition (MSH) Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Concepts Therapeutic or Preventive Procedure (T061)
MSH D018380
SnomedCT 234336002
English Hematopoietic Stem Cell Transplantation, Stem Cell Transplantation, Hematopoietic, Transplantation, Hematopoietic Stem Cell, Haemopoietic stem cell transpl, Hemopoietic stem cell transpl, STEM CELL TRANSPL HEMATOPOIETIC, HEMATOPOIETIC STEM CELL TRANSPL, hematopoietic stem cell transplant, hematopoietic stem cell transplant (treatment), hematopoietic stem cell transplantation, HCT, Hematopoietic Cell Transplantation, HSCT, Hematopoietic stem cells--Transplantation, Haemopoietic stem cell transplant, Hemopoietic stem cell transplant (procedure), Transfusion of stem cells, Hemopoietic stem cell transplant
Swedish Blodstamcellstransplantation
Spanish trasplante de hemocitoblastos, transplante de hemocitoblastos, trasplante de hemocitoblastos (procedimiento), trasplante de células pluropotenciales hematopoyéticas, trasplante de células madre hematopoyéticas (procedimiento), trasplante de células precursoras hemopoyéticas, trasplante de células precursoras hemopoyéticas (procedimiento), trasplante de células madre hematopoyéticas, Trasplantación de Células Madre Hematopoyéticas, transplante de hemocitoblastos (procedimiento), Trasplantación de Célula Madre Hematopoyética, Trasplante de Células Madre Hematopoyéticas
Czech hematopoetické kmenové buňky - transplantace
Finnish Hematopoieettisten kantasolujen siirto
Russian PERIFERICHESKIKH STVOLOVYKH KLETOK TRANSPLANTATSIIA, TRANSPLANTATSIIA KROVETVORNYKH STVOLOVYKH KLETOK, KROVETVORNYKH STVOLOVYKH KLETOK TRANSPLANTATSIIA, GEMOPOETICHESKIKH STVOLOVYKH KLETOK TRANSPLANTATSIIA, STVOLOVYKH KLETOK KROVETVORNYKH TRANSPLANTATSIIA, STVOLOVYKH KLETOK KROVI TRANSPLANTATSIIA, ГЕМОПОЭТИЧЕСКИХ СТВОЛОВЫХ КЛЕТОК ТРАНСПЛАНТАЦИЯ, КРОВЕТВОРНЫХ СТВОЛОВЫХ КЛЕТОК ТРАНСПЛАНТАЦИЯ, ПЕРИФЕРИЧЕСКИХ СТВОЛОВЫХ КЛЕТОК ТРАНСПЛАНТАЦИЯ, СТВОЛОВЫХ КЛЕТОК КРОВЕТВОРНЫХ ТРАНСПЛАНТАЦИЯ, СТВОЛОВЫХ КЛЕТОК КРОВИ ТРАНСПЛАНТАЦИЯ, ТРАНСПЛАНТАЦИЯ КРОВЕТВОРНЫХ СТВОЛОВЫХ КЛЕТОК
Japanese 血液幹細胞移植, 幹細胞移植-造血, 造血幹細胞移植, 移植-造血幹細胞
French Transplantation de cellules souches hématopoïétiques, Greffe de cellules souches hématopoïétiques (procédure), Greffe de cellules souches hématopoïétiques
Croatian HEMATOPOETSKE MATIČNE STANICE, TRANSPLANTACIJA, TRANSPLANTACIJA KRVOTVORNIH MATIČNIH STANICA
Polish Przeszczepianie obwodowych komórek pnia, Przeszczepianie krwiotwórczych komórek macierzystych, Przeszczepianie komórek pnia szpiku, Przeszczep krwiotwórczych komórek macierzystych, Transplantacja krwiotwórczych komórek macierzystych
Norwegian Stamcellestransplantasjon, hematopoetisk, Hematopoetisk stamcellestransplantasjon
Portuguese Transplantação de Células-Tronco Hematopoéticas, Transplante de Célula-Tronco Hematopoiética, Transplantação de Células-Tronco Hematopoiéticas, Transplante de Células-Tronco Hematopoiéticas, Transplante de Célula-Tronco Hematopoética, Transplante de Células-Tronco Hematopoéticas
German Transplantation hämatopoetischer Stammzellen
Italian Trapianto di cellule staminali ematopoietiche
Dutch Hemopoëtische stamceltransplantatie, Stamceltransplantatie, hemopoëtische, Transplantatie, stamcel-, hemopoëtische

Ontology: Stem cell transplant (C1504389)

Definition (MSHCZE) Přenos kmenových buněk mezi jedinci stejného druhu (TRANSPLANTACE HOMOLOGNÍ) nebo mezi různými druhy (TRANSPLANTACE HETEROLOGNÍ) nebo přenos v rámci téhož jedince (TRANSPLANTACE AUTOLOGNÍ). Zdroj a umístění kmenových buněk určuje jejich potenci či pluripotenci v souvislosti s jejich další diferenciací v různé typy buněk.
Definition (MSH) The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Definition (CSP) transfer of stem cells from one individual to another within the same species or between species, or transfer within the same individual; the source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Concepts Therapeutic or Preventive Procedure (T061)
MSH D033581
LNC LA4478-9
English Stem Cell Transplantation, Stem Cell Transplantations, Transplantation, Stem Cell, Transplantations, Stem Cell, TRANSPL STEM CELL, STEM CELL TRANSPL, cells stem transplantation, cell stem transplantation, stem cell transplantation, cells stem transplantations, stem cell transplantations, Stem cells--Transplantation, Stem Cell Transplant, Stem cell transplant
German Stammzell-Transplantation, Stammzellentransplantation, Stammzelltransplantation, Transplantation, Stammzell-
Swedish Stamcellstransplantation
Japanese カンサイボウイショク, 幹細胞移植
Finnish Kantasolujen siirto
Russian STVOLOVYKH KLETOK EMBRIONA TRANSPLANTATSIIA, STVOLOVYKH KLETOK VZROSLYKH OSOBEI TRANSPLANTATSIIA, STVOLOVYKH KLETOK TRANSPLANTATSIIA, STVOLOVYKH KLETOK PODROSTKOV TRANSPLANTATSIIA, STVOLOVYKH KLETOK PLODA TRANSPLANTATSIIA, СТВОЛОВЫХ КЛЕТОК ВЗРОСЛЫХ ОСОБЕЙ ТРАНСПЛАНТАЦИЯ, СТВОЛОВЫХ КЛЕТОК ПЛОДА ТРАНСПЛАНТАЦИЯ, СТВОЛОВЫХ КЛЕТОК ПОДРОСТКОВ ТРАНСПЛАНТАЦИЯ, СТВОЛОВЫХ КЛЕТОК ТРАНСПЛАНТАЦИЯ, СТВОЛОВЫХ КЛЕТОК ЭМБРИОНА ТРАНСПЛАНТАЦИЯ
Spanish Trasplante de células madres, Trasplantación de Célula Madre, Trasplantación de Células Madre, Trasplante de Células Madre
Czech Transplantace kmenových buněk, transplantace kmenových buněk, kmenové buňky - transplantace
French Transplantation de cellules souches, Greffe de cellules souches (procédure), Greffe de cellules souches
Croatian Not Translated[Stem Cell Transplantation]
Polish Przeszczepianie komórek macierzystych
Hungarian Őssejt transzplantáció
Norwegian Transplantasjon, stamcelle, Stamcelletransplantasjon
Portuguese Transplantação de Célula Madre, Transplante de células mães, Transplante de Células-Tronco, Transplantação de Células-Tronco
Dutch stamceltransplantaat, Stamceltransplantatie, Transplantatie, stamcel-
Italian Trapianto di cellule staminali