II. Pathophysiology

  1. Normal Bone Marrow replaced by fibrotic material

III. Symptoms and Signs

  1. Weight loss
  2. Excessive Bleeding from skin and mucous membranes

IV. Diagnosis

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Ontology: Myelofibrosis (C0026987)

Definition (NCI) A partial or complete replacement of the bone marrow stroma by fibrous tissue. It can be a primary bone marrow lesion as part of the chronic myeloproliferative disorders (chronic idiopathic myelofibrosis), a manifestation of acute myeloid leukemia (acute panmyelosis with myelofibrosis), or a secondary phenomenon due to bone marrow involvement by a metastatic tumor (e.g., metastatic breast carcinoma). --2003
Definition (NCI_NCI-GLOSS) A disorder in which the bone marrow is replaced by fibrous tissue.
Definition (CSP) replacement of the bone marrow by fibrous tissue, occurring in association with a myeloproliferative disorder or secondary to another unrelated condition.
Concepts Neoplastic Process (T191)
MSH D009191
ICD9 289.83, 238.76
ICD10 D75.81
SnomedCT 267572005, 78956007, 154841009, 52967002
English Myelofibrosis, Agnogenic myeloid metaplasia, Myelofibrosis with myeloid metaplasia, Myelosis-non-leukemic, myelofibrosis, myelofibrosis (diagnosis), Myelosis non-leukaemic, Myelosis-non-leukaemic, Myelosis non-leukemic, Myelosis nonleukemic, MMM, MYELOFIBROSIS, MYELOFIBROSIS WITH MYELOID METAPLASIA, Myelofibrosis NOS, chronic idiopathic myelofibrosis, fibrosis bone marrow, bone fibrosis marrow, bone marrow fibrosis, mos, Myelosclerosis (disorder), Myelosclerosis, MF - Myelofibrosis, Myelofibrosis (disorder), myelosclerosis, Myelofibrosis, NOS, Myelosclerosis, NOS
French MYELOFIBROSE, Myélose non leucémique, Myélofibrose
Portuguese MIELOFIBROSE, Mielose não leucémica, Mielofibrose
Spanish MIELOFIBROSIS, Mielosis no leucémica, mielosclerosis (concepto no activo), mielosclerosis, esclerosis de la médula ósea, fibrosis de la médula ósea, mielofibrosis (trastorno), mielofibrosis, Mielofibrosis
German MYELOFIBROSE, Myelose nicht-leukaemisch, Myelofibrose
Italian Mielofibrosi, Mielosi non leucemica
Dutch myelosis niet-leukemisch, myelosis-niet-leukaemisch, myelosis niet-leukaemisch, myelofibrose
Japanese 骨髄線維症, コツズイセンイショウ, 非白血病性骨髄症, ヒハッケツビョウセイコツズイショウ
Finnish Myelofibroosi
Czech Neleukemická myelóza, Myelofibróza
Hungarian Nem leukaemiás myelosis, Nem-leukaemiás myelosis, Myelofibrosis, Nem leukemiás myelosis, Nem-leukemiás myelosis