II. Epidemiology

  1. Chronic Leukemia is primarily an adult cancer

IV. Symptoms

  1. Asymptomatic at presentation (incidentally diagnosed based on CBC with Leukocytosis)
    1. Chronic Lymphocytic Leukemia
      1. Asymptomatic at diagnosis: 50%
    2. Chronic Myelogenous Leukemia
      1. Asymptomatic at diagnosis: 20%
  2. Constitutional symptoms
    1. Much less common in Chronic Leukemia than with Acute Leukemia)
    2. Chronic Lymphocytic Leukemia: 15%
    3. Chronic Myelogenous Leukemia: 30%

VI. Labs

  1. Complete Blood Count
    1. Leukocytosis >20,000/mm3 in most cases (often >100,000/mm3)
    2. Contrast with normal white cell counts or Leukopenia associated with Acute Leukemias

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Ontology: Chronic leukemia (category) (C1279296)

Definition (NCI) A slowly progressing leukemia characterized by a clonal (malignant) proliferation of maturing and mature myeloid cells or mature lymphocytes. When the clonal cellular population is composed of myeloid cells, the process is called chronic myelogenous leukemia. When the clonal cellular population is composed of lymphocytes, it is classified as chronic lymphocytic leukemia, hairy cell leukemia, or T-cell large granular lymphocyte leukemia.
Definition (NCI_NCI-GLOSS) A slowly progressing cancer that starts in blood-forming tissues such as the bone marrow, and causes large numbers of white blood cells to be produced and enter the blood stream.
Definition (CSP) leukemia in which the involved cell is well differentiated, usually B-lymphocytes, but immunologically incompetent; types distinguished include chronic granulocytic, chronic lymphocytic, chronic myelomonocytic, eosinophilic and hairy cell leukemia.
Concepts Neoplastic Process (T191)
ICD9 208.1
ICD10 M9803/3 , C95.1, C95.10
SnomedCT 92812005, 2557004, 128933000, 190027002, 188764001, 154600002
English Leukemia of unspecified cell type, chronic, Chronic leukaemia NOS, Chronic leukemia NOS, Chronic leukaemia of unspecified cell type, Chronic leukemia of unspecified cell type, [M]Chronic leukaemia NOS, [M]Chronic leukemia NOS, chronic leukemia (diagnosis), leukemia chronic, chronic leukemia, Chronic leukaemia, disease, Chronic leukemia, disease, Chronic leukemia - category, Chronic leukaemia -RETIRED-, Chronic leukaemia - category, Leukaemia of unspecified cell type, chronic, Leukaemia chronic, Leukemia chronic, chronic leukaemia, chronic leukemias, [M]Chronic leukaemia NOS (disorder), Chronic leukemia NOS (disorder), Chronic leukemia (morphologic abnormality), Chronic leukaemia NOS (disorder), Chronic leukemia, Chronic leukaemia, Chronic leukaemia (category), Chronic leukemia (category), Chronic leukemia - category (morphologic abnormality), Chronic leukemia, disease (disorder), leukemia, chronic, chronic; leukemia, leukemia; chronic, Chronic leukemia, NOS, Chronic leukemia -RETIRED-, Chronic Leukemia
Spanish leucemia crónica (categoría, anomalía morfológica), leucemia crónica, enfermedad, Leucemia crónica NEOM, Leucemia crónica de tipo de célula no especificado, Leucemia crónica de tipo celular no especificado, Leucemia de tipo celular no especificado, crónica, leucemia crónica (concepto no activo), leucemia crónica, SAI, Chronic leukemia NOS, leucemia crónica, SAI (trastorno), Chronic leukaemia NOS, leucemia crónica (categoría), leucemia crónica (categoría, anomalía morfológica) (anomalía morfológica), leucemia crónica, enfermedad (trastorno), leucemia crónica, Leucemia crónica
Italian Leucemia cronica, Leucemia a tipo cellulare non specificato, cronica, Leucemia cronica di tipo cellulare non specificato, Leucemia cronica NAS, Leucemia di tipo cellulare non specificato, cronica
Dutch chronische leukemie NAO, leukemie ongekend celtype, chronisch, leukemie chronisch, chronische leukemie van niet-gespecificeerd celtype, chronische leukemie ongekend celtype, chronisch; leukemie, leukemie; chronisch, Chronische leukemie van niet gespecificeerd celtype, chronische leukemie
French Leucémie chronique SAI, Leucémie à cellules de type non précisé, chronique, Leucémie chronique de type cellulaire non précisé, Leucémie chronique à cellules de type non précisé, Leucémie chronique
German Leukaemie, chronisch, chronische Leukaemie eines unspezifischen Zelltyps, chronische Leukaemie NNB, Leukaemie eines unspezifischen Zelltyps, chronisch, Chronische Leukaemie nicht naeher bezeichneten Zelltyps, chronische Leukaemie
Portuguese Leucemia crónica NE, Leucemia crónica de tipo celular NE, Leucemia de tipo celular NE crónica, Leucemia crónica de tipo celular não especificado, Leucemia crónica
Japanese 慢性白血病, 慢性白血病、細胞タイプ不明, 慢性白血病NOS, マンセイハッケツビョウNOS, マンセイハッケツビョウサイボウタイプフメイ, マンセイハッケツビョウ
Czech Chronická leukemie, Chronická leukemie blíže neurčeného buněčného typu, Chronická leukemie NOS, Chronická leukemie vycházející z blíže neurčeného buněčného typu
Korean 상세불명 세포형의 만성 백혈병
Hungarian Chronikus leukaemia k.m.n., Idült fehérvérűség, Nem meghatározott sejttípusú, chronikus leukemia, Chronikus leukemia k.m.n., Idült leukaemia, Chronikus fehérvérűség, Chronikus leukaemia, Nem meghatározott sejt típus chronikus leukemia, Nem meghatározott sejttípus chronikus leukaemia, Nem meghatározott sejttípusú chronikus leukemia