II. Causes: Decreased Neutrophil Production

  1. Marrow Infiltration
    1. Leukemia
    2. Myelodysplastic Syndrome
    3. Myelofibrosis (tumor invasion)
    4. Granulomatous infiltration (e.g. Tuberculosis)
  2. Marrow Injury
    1. Radiation
    2. Aplastic Anemia
    3. Paroxysmal Nocturnal Hemoglobinuria
    4. Medications
      1. See Drug-Induced Agranulocytosis
    5. Infection
      1. See Infectious Causes of Neutropenia

III. Causes: Increased Neutrophil Destruction

  1. Severe Sepsis (increased consumption)
  2. Antineutrophil Antibody
  3. Hypersplenism (Splenic trapping)
  4. Felty's Syndrome
  5. Systemic Lupus Erythematosus
  6. Chediak-Higashi Syndrome (rare Autosomal Recessive)
  7. Medications
    1. Phenylbutazone
    2. Phenothiazine

IV. Causes: Lower Clinical Significance

  1. Pseudoneutropenia (based on automated count)
  2. Maturation Defect
    1. Vitamin B12 Deficiency
    2. Folic Acid Deficiency
  3. Margination (distribution)
    1. Bacterial Infection (endotoxin)
    2. Hemodialysis
    3. Cardiopulmonary bypass

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Ontology: Agranulocytosis (C0001824)

Definition (NCI_NCI-GLOSS) A condition in which there is a lower-than-normal number of granulocytes (a type of white blood cell).
Definition (NCI) A decrease in the number of mature granulocytes (neutrophils, eosinophils, and basophils) in the peripheral blood.
Definition (CSP) decrease in the number of granulocytes (basophils, eosinophils, and neutrophils).
Definition (MSH) A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).
Concepts Disease or Syndrome (T047)
MSH D000380
ICD10 D70
SnomedCT 191350006, 154830007, 165508008, 142919000, 310589001, 191336001, 17182001, 72885007, 417672002
English Agranulocytoses, Agranulocytosis, Granulocytopenia, Granulocytopenias, AGRANULOCYTOSIS, GRANULOCYTOPENIA, Agranulocytosis NOS, agranulocytosis (diagnosis), agranulocytosis, granulocytopenia (diagnosis), granulocytopenia, Agranulocytosis [Disease/Finding], granulopenia, agranulocytoses, Agranulocytosis NOS (disorder), Agranulocytosis (finding), Granulocytopenia (disorder), Granulopenia, Agranulocytosis (disorder), Schultz, Granulocytopenic disorder (disorder), Granulocytopenic disorder
French AGRANULOCYTOSE, GRANULOCYTOPENIE, Agranulocytose, Granulocytopénie
Portuguese AGRANULOCITOSE, GRANULOCITOPENIA, Agranulocitose, Granulocitopenia
Spanish AGRANULOCITOSIS, GRANULOCITOPENIA, agranulocitosis (hallazgo), granulocitopenia, agranulocitosis, SAI (trastorno), granulopenia, agranulocitosis, SAI, granulocitopenia (trastorno), agranulocitosis (trastorno), agranulocitosis, trastorno granulocitopénico (trastorno), trastorno granulocitopénico, Agranulocitosis, Granulocitopenia
German AGRANULOZYTOSE, GRANULOZYTOPENIE, Agranulozytose, Granulozytopenie
Swedish Agranulocytos
Japanese カリュウキュウゲンショウショウ, ムカリュウキュウショウ, Schultz症候群, 顆粒球減少症, シュルツ症候群, 無顆粒球症, 顆粒球減少
Czech agranulocytóza, granulocytopenie, Agranulocytóza, Granulocytopenie
Finnish Agranulosytoosi
Italian Granulocitopenia, Agranulocitosi
Russian AGRANULOTSITOZ, GRANULOTSITOPENIIA, АГРАНУЛОЦИТОЗ, ГРАНУЛОЦИТОПЕНИЯ
Korean 무과립세포증
Croatian AGRANULOCITOZA
Polish Agranulocytoza, Granulocytopenia
Hungarian granulocytopenia, agranulocytosis
Norwegian Agranulocytose, Granulocytopeni
Dutch agranulocytose, granulocytopenie, Agranulocytose, Cytose, agranulo-, Granulocytopenie

Ontology: Neutropenia (C0027947)

Definition (MSH) A decrease in the number of NEUTROPHILS found in the blood.
Definition (CSP) decrease in the number of neutrophilic leukocytes in the blood.
Concepts Disease or Syndrome (T047)
MSH D009503
ICD9 288.0, 288.00
ICD10 D70 , D70.9
SnomedCT 191336001, 72885007, 142928004, 303011007
English Neutropenias, NEUTROPENIA, neutropenia (diagnosis), neutropenia, Neutropenia, Neutropenia NOS, Neutropenia, unspecified, Neutropenia [Disease/Finding], Neutropenia (disorder), Neutropenia (finding), Disorder characterized by neutropenia, Neutropenic disorder, Neutropenic disorder (disorder), Neutropenia, NOS, Neutropenia (disorder) [Ambiguous]
French NEUTROPENIE, Neutropénie, Neutropénies
Portuguese NEUTROPENIA, Neutropenia, Neutropenias
Spanish NEUTROPENIA, neutropenia (trastorno), neutropenia, neutropenia (concepto no activo), neutropenia - trastorno (trastorno), neutropenia - trastorno, trastorno neutropénico, Neutropenias, Neutropenia
German NEUTROPENIE, Neutropenie, Neutropenien
Italian Neutropenia, Neutropenie
Japanese 好中球減少症, コウチュウキュウゲンショウショウ
Swedish Neutropeni
Czech Snížený počet neutrofilů, Neutropenie
Polish Neutropenia
Hungarian Neutropeniák, neutropenia
Dutch neutropenie, neutropenieën, Neutropenie
Russian НЕЙТРОПЕНИЯ