II. Mechanism

  1. Acute phase reactant

III. Normal

  1. Normal: 200-400 mg/dl

IV. Increased Fibrinogen

  1. Tissue inflammation or damage
  2. Acute infection
  3. Myocardial Infarction
  4. Medications
    1. Oral Contraceptives
  5. Pregnancy

V. Decreased Fibrinogen

  1. Disseminated Intravascular Coagulation
  2. Primary or Secondary Fibrinolysis
  3. Liver disease
  4. Hereditary afibrinogenemia or Hypofibrinogenemia
  5. Cachexia

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Ontology: fibrinogen complex location (C1167394)

Definition (GO) A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds. [ISBN:0198547684]
Concepts Cell Component (T026)
English fibrinogen complex, fibrinogen, fibrinogen complex location