II. Autoimmune Hemolytic Anemia

III. Mechanical Trauma

IV. Miscellaneous Causes

  1. Hypersplenism
  2. Direct toxic effects
    1. Malaria
    2. Clostridium difficile
    3. Toxoplasmosis
  3. RBC Membrane abnormalities
    1. Spur CellAnemia
      1. Anorexia Nervosa
      2. Cirrhosis
    2. Paroxysmal Nocturnal Hemoglobinuria
    3. Hereditary spherocytosis
  4. RBC Intracellular abnormalities
    1. Enzyme Defects
      1. G6PD Deficiency
      2. Pyruvate kinase deficiency
    2. Hemoglobinopathy
    3. Sickle Cell Anemia
    4. Thalassemia

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