II. Pathophysiology

  1. Parvovirus B19 infection interrupts Red Blood Cell production
  2. Results in high Red Blood Cell turn-over

III. Differential Diagnosis

  1. Sickle Cell Hemolytic Crisis
  2. Splenic Sequestration

IV. Labs

  1. Hemoglobin decreased from baseline
  2. Reticulocyte Count decreased (approaches 0)
    1. Secondary to decreased Red Blood Cell production despite acute Anemia
    2. Contrast with Sickle Cell Hemolytic Crisis and Splenic Sequestration where the Reticulocyte Count is increased

V. Management

  1. Admit with isolation droplet precautions (due to Parvovirus B19)
    1. Avoid exposing pregnant women
  2. Consult hematology
  3. Intravenous Immunoglobulin (IVIG)
  4. Blood Transfusion may be needed
    1. Blood should be cross-matched, Leukocyte depleted, and irradiated

VI. References

  1. Glassberg and Weingart in Majoewsky (2012) EM: Rap 12(8): 5-6

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Ontology: Transient acquired pure red cell aplasia (C0451688)

Concepts Disease or Syndrome (T047)
ICD10 D60.1
SnomedCT 191255003
English Trnsnt acqd pur red cell aplas, transient acquired pure red blood cell aplasia, red blood cell aplasia acquired transient pure, transient acquired pure red blood cell aplasia (diagnosis), Transient acquired pure red cell aplasia, Transient acquired pure red cell aplasia (disorder)
German Transitorische erworbene isolierte aplastische Anaemie
Korean 일과성 후천성 순수적혈구 무형성
Dutch Voorbijgaande verworven 'pure red cell aplasia'
Spanish aplasia eritrocítica pura, adquirida, transitoria (trastorno), aplasia eritrocítica pura, adquirida, transitoria