II. Physiology: Pathway

  1. Factor Xa
    1. Cofactor: Factor V
    2. Inhibitors
      1. Protein C
      2. Protein S
      3. Medications: Direct Xa Inhibitors
  2. Factor II (Prothrombin) converted to IIa (Thrombin)
    1. Fibrinogen cleaved
      1. Fibrinogen cleaved to Fibrin Monomer
      2. Fibrin Monomer coalesced into Fibrin Polymer
    2. Factor XIII converted to XIIIa
      1. Fibrin polymer cross-linked

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