II. General

  1. Ability to prevent spotting or breakthrough bleeding
  2. Dependent on Estrogen-Progestin ratio
  3. Bleeding may be due to:
    1. Estrogen insufficiency
    2. Progesterone insufficiency

III. Progestins with least potent Endometrial Activity

  1. Amount to suppress bleeding for 20 days in 50% women
  2. Gestodene (12.6)
  3. Desogestrel (8.7)
  4. Levonorgestrel (5.1)
  5. dl-Norgestrel (2.6)

IV. Progestins with most Endometrial Activity

  1. Amount to suppress bleeding for 20 days in 50% women
  2. Norethynodrel (0): Low limit reference
  3. Norethindrone Acetate (0.4)
  4. Ethynodiol Diacetate (0.4)
  5. Norethindrone (1.0)

V. Oral Contraceptives with least Endometrial Activity

  1. Least suppression of bleeding
  2. Progestin-Only (Mini-Pill)
  3. Demulen 1/35
  4. Loestrin
  5. Tri-Norinyl

VI. Oral Contraceptives with most Endometrial Activity

  1. Greatest suppression of bleeding
  2. Ovral
  3. Lo-Ovral
  4. Ortho Novum
  5. Ovcon
  6. Norlestrin
  7. Demulen 50

VII. References

Images: Related links to external sites (from Bing)

Related Studies (from Trip Database) Open in New Window