II. Indications

III. Pathophysiology

  1. Synthetic isoxazol derivative of ethisterone
  2. Inhibits gonadotropic secretion
  3. Prevents Menstrual Bleeding
  4. Mildly androgenic

IV. Dosing

  1. Danazol 400-600 mg qd

V. Efficacy

  1. Expensive ($100/month)
  2. Same rate of pregnancy as with Provera or Surgery

VI. Adverse Effects: Androgenic effects

  1. Acne Vulgaris
  2. Flushes
  3. Sweats
  4. Edema
  5. Libido changes

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Cost: Medications

danazol (on 8/19/2015 at Medicaid.Gov Survey of pharmacy drug pricing)
DANAZOL 200 MG CAPSULE Generic $4.54 each

Ontology: Danazol (C0010961)

Definition (NCI) A synthetic androgen derived from ethinyl testosterone. Danazol indirectly reduces estrogen production by decreasing pituitary secretion of follicle-stimulating hormone and luteinizing hormone, and binds to sex hormone receptors in target tissues, thereby exhibiting antiestrogenic, anabolic and weakly androgenic effects. (NCI04)
Definition (NCI_NCI-GLOSS) A synthetic hormone that belongs to the family of drugs called androgens and is used to treat endometriosis. It is being evaluated in the treatment of endometrial cancer.
Definition (MSH) A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.
Definition (PDQ) A synthetic androgen derived from ethinyl testosterone. Danazol indirectly reduces estrogen production by decreasing pituitary secretion of follicle-stimulating hormone and luteinizing hormone, and binds to sex hormone receptors in target tissues, thereby exhibiting antiestrogenic, anabolic and weakly androgenic effects. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39204&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39204&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C414" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Hormone (T125) , Steroid (T110)
MSH D003613
SnomedCT 87881000, 126124009
LNC LP172589-6, MTHU046384
English Pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol, (17alpha)-, danazol, 17Alpha-ethynyl-17beta-hydroxy-4-androsteno[2,3-d]isoxazole, 1-Ethynyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-10a,12a-dimethyl-1H-cyclopental[7,8]phenanthro[3,2-d]isoxazol-1-ol, (17Alpha)-pregna-2,4-dien-20-yno[2,3-d]-isoxazol-17-ol, DAN, danazol (medication), Danazol [Chemical/Ingredient], DANAZOL, (17alpha)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol, Danazol preparation, Danazol product, Danazol (substance), Danazol preparation (product), Danazol preparation (substance), Danazol
Swedish Danazol
Czech danazol
Finnish Danatsoli
Russian DANAZOL, ДАНАЗОЛ
Japanese ダナゾール
Spanish danazol (producto), preparado con danazol (producto), preparado con danazol, danazol (sustancia), danazol, preparado de danazol (producto), preparado de danazol (sustancia), preparado de danazol, Danazol
Polish Danazol
French Danazol
German Danazol
Italian Danazolo
Portuguese Danazol