I. Indications

II. Dose

  1. Adults: 40-125 mg po qid
  2. Infants: 0.3 ml PO qid prn

III. Pharmacokinetics

  1. Not absorbed

IV. Efficacy

  1. Several controlled clinical trials have been performed
  2. No evidence that Simethicone is better than Placebo

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Cost: Medications

simethicone (on 1/21/2015 at Medicaid.Gov Survey of pharmacy drug pricing)
SIMETHICONE 125 MG TAB CHEW Generic OTC $0.06 each
SIMETHICONE 180 MG SOFTGEL Generic OTC $0.05 each
SIMETHICONE 40 MG/0.6 ML DROP Generic OTC $0.07 per ml
SIMETHICONE 80 MG TAB CHEW Generic OTC $0.02 each
gas-x (on 12/17/2014 at Medicaid.Gov Survey of pharmacy drug pricing)
GAS-X EX-STR 125 MG TAB CHEW Generic OTC $0.05 each
GAS-X EXTRA STRENGTH SOFTGEL Generic OTC $0.08 each
GAS-X TABLET CHEWABLE Generic OTC $0.02 each
GAS-X ULTRA STRENGTH SOFTGEL Generic OTC $0.05 each

Ontology: Simethicone (C0037138)

Definition (MSH) A poly(dimethylsiloxane) which is a polymer of 200-350 units of dimethylsiloxane, along with added silica gel. It is used as an antiflatulent, surfactant, and ointment base.
Definition (NCI) A mixture of polydimethylsiloxanes with antifoaming and anti-bloating effects. Simethicone reduces the surface tension of gas bubbles causing them to coalesce into larger bubbles that can be passed more easily by belching or flatulence.
Concepts Pharmacologic Substance (T121) , Biomedical or Dental Material (T122) , Organic Chemical (T109)
MSH D012841
SnomedCT 387442005, 77898008
LNC LP171639-0
English Simeticone, Simethicone, simethicone (medication), Simethicone [Chemical/Ingredient], dimethicone activated, activated dimethicone, simethicone, Activated dimethicone, Activated methylpolysiloxane, Simethicone (product), Simethicone (substance), SIMETHICONE
Swedish Simetikon
Czech simethikon
Finnish Simetikoni
Russian SIMETIKON, DIMETIKON, ДИМЕТИКОН, СИМЕТИКОН
Japanese シメチコン
Spanish dimeticona, dimeticona activada, metilpolisiloxano activado, simeticona (producto), simeticona (sustancia), simeticona, Simeticona
Polish Simeticon, Simetykon
Norwegian Simetikon
French Siméticone
German Simethicon
Italian Simeticone
Portuguese Simeticone

Ontology: Mylicon (C0721886)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Mylicon, mylicon

Ontology: Phazyme (C0722576)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Phazyme, phazyme