II. Indication

III. Mechanism

  1. Reduces maximal anal resting pressure

IV. Dosing

  1. Glyceryl Trinitrate ointment 0.2% bid for 6 weeks

V. Efficacy

  1. Study of 80 patients with Anal Fissures
    1. At 8 weeks, fissures healed in 68% versus 8% Placebo
  2. References
    1. Lund (1997) Lancet 349-11-4 [PubMed]

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Ontology: Nitroglycerin (C0017887)

Definition (NCI_NCI-GLOSS) In medicine, a substance used as a drug to treat certain heart conditions and to widen the openings in blood vessels. Nitroglycerin is being studied as a way to help chemotherapy work better by making tumor cells more sensitive to the drugs. It is a type of vasodilator.
Definition (NCI) An organic nitrate with vasodilator activity. Nitroglycerin is converted into nitric oxide (NO) in smooth muscle and activates guanylyl cyclase, thereby increasing cGMP concentration, and resulting in smooth muscle relaxation. Dilatation of the veins results in decreased venous return to the heart, thereby decreasing left ventricular volume (reduced preload) and decreasing myocardial oxygen requirements. Arteriolar relaxation reduces arteriolar resistance (reduced afterload), thereby decreasing myocardial oxygen demands. In addition, nitroglycerine causes coronary artery dilatation, thereby improving myocardial blood distribution.
Definition (CSP) volatile vasodilator which relieves angina pectoris by stimulating guanylate cyclase and lowering cytosolic calcium; an explosive compound rendered safe when compounded in tablets with mannitol.
Definition (MSH) A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D005996
SnomedCT 71759000, 387623004, 319379008, 387404004
LNC LP18092-4, MTHU003375
English Glyceryl Trinitrate, Nitroglycerin, Trinitrate, Glyceryl, 1,2,3-Propanetriol, trinitrate, Glyceryl trinitr [generic add], nitroglycerin, Glyceryl trinitrate [generic additions], NITROGLYCERIN, 1,2,3-propanetriol trinitrate, nitroglycerin (medication), Nitroglycerin [Chemical/Ingredient], nitroglycerol, nitroglycerine, glyceryl trinitrate, Glyceryl trinitrate (product), Glyceryl trinitrate [generic additions] (product), Glyceryl trinitrate, Nitroglycerol, GTN - Glyceryl trinitrate, Glyceryl trinitrate product, Nitroglycerin (product), Nitroglycerin (substance), Glyceryl trinitrate [generic additions] (substance)
Swedish Nitroglycerin
Czech nitroglycerin, glyceryltrinitrát
Finnish Glyseryylitrinitraatti
French Trinitrate de glycéryle, Trinitrate de glycérol, Trinitroglycérol, Nitroglycérine, Nitroglycérol, Trinitrine, Trinitroglycérine
Russian GLITSERIL TRINITRAT, NITROGLITSERIN, ГЛИЦЕРИЛ ТРИНИТРАТ, НИТРОГЛИЦЕРИН
Japanese トリニトログリセリン, ニトログリセリン, ニトログリセロール
Croatian NITROGLICERIN
Polish Nitrogliceryna, Trójazotan glicerolu, Nitrocard
Spanish trinitrato de glicerilo (agregados genéricos) (producto), trinitrato de glicerilo, trinitrato de glicerilo (producto), trinitrato de glicerilo (agregados genéricos), gliceriltrinitrato, nitroglicerina (producto), nitroglicerina (sustancia), nitroglicerina, nitroglicerol, Nitroglicerina, Trinitrato de Glicerilo
German Glyzerintrinitrat, Nitroglycerin
Italian Nitroglicerina
Portuguese Nitroglicerina, Trinitrato de Gliceril