II. Epidemiology

  1. Enteric transmission of non-A, non-B Hepatitis
    1. Most common cause in world
  2. Waterborne Illness epidemics in
    1. India
    2. Asia
    3. Africa
    4. Mexico

III. Course

  1. Self-limited illness
  2. Mortality 10-20% in pregnant women
  3. No associated chronic hepatitis

IV. Pathophysiology

  1. Incubation period: 15-60 days (mean 40 days)
  2. Infectivity: Virus excretion in stool for <14 days
  3. Calicivirus (diameter 32-34 nm))

V. Signs and Symptoms

VI. Differential Diagnosis

VII. Management

  1. High calorie diet (better tolerated in morning)
  2. IV Hydration when indicated for severe dehydration
  3. Cholestyramine up to 4g PO qid for severe Pruritus
  4. Avoid drugs with hepatic metabolism

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Ontology: Hepatitis E virus (C0085294)

Definition (NCI) A member of the genus Hepevirus, it is a single-stranded, positive-sense RNA virus with icosahedral shape that causes Hepatitis E.
Definition (NCI_NCI-GLOSS) A virus that causes hepatitis (inflammation of the liver). It is usually spread through food that has been handled by an infected person, or through drinking water that is contaminated with human waste.
Definition (NCI_CDISC) Any viral organism that can be assigned to the species Hepatitis E virus.
Definition (CSP) positive stranded RNA virus species in an unassigned genus, Hepatitis E like Viruses, causing enterically transmitted non A, non B hepatitis (hepatitis E).
Definition (MSH) A positive-stranded RNA virus species in the genus HEPEVIRUS, causing enterically-transmitted non-A, non-B hepatitis (HEPATITIS E).
Concepts Virus (T005)
MSH D016752
SnomedCT 78475006
LNC LP18317-5
Swedish Hepatit E-virus
Czech virus hepatitidy E
Finnish Hepatiitti E -virus
French Virus de l'hépatite E, Hepatitis E virus, HEV (Hepatitis E Virus), VHE (Virus de l'Hépatite E)
Russian GEPATITA E VIRUS, ГЕПАТИТА E ВИРУС
English hepatitis e virus, hepatitis E virus (HEV), hev, Hepatitis E virus HEV, HEPATITIS E VIRUS, hepatitis E virus, HEV, HEV - Hepatitis E virus, Hepatitis E virus (organism), Hepatitis E Virus, Hepatitis E virus
Polish Virus hepatitis E, HEV, Wirus zapalenia wątroby E, Wirus zapalenia wątroby typu E
Norwegian Hepatitt E-virus
Spanish virus de la hepatitis E (organismo), virus de la hepatitis E, Virus de la Hepatitis E
German Hepatitis-E-Virus
Italian Virus dell'epatite E
Dutch Hepatitis-E-virus, Virus, Hepatitis-E-
Portuguese Vírus da Hepatite E