II. Definition

  1. Least specific marker of hepatocyte injury

III. Normal Total LDH

  1. Range: 300-600 U/L (varies widely per lab)

IV. Increased Total LDH

  1. Myocardial Infarction
  2. Lung Infarction
  3. Kidney infarction
  4. Cerebrovascular Accident
  5. Cardiopulmonary disease
  6. Liver disease (non-specific)
    1. Dramatically increased in ischemic hepatitis
    2. Increased with alk phos in liver metastases
  7. Collagen-vascular disease
  8. Hemolytic Anemia
  9. Megaloblastic Anemia
  10. Transfusions
  11. Acute Pancreatitis
  12. Intestinal Obstruction
  13. Muscle Trauma
  14. Hypotension or shock
  15. Epstein Barr Virus (EBV)
  16. Cytomegalovirus (CMV)
  17. Neoplasm
  18. Hypothyroidism

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Ontology: Lactate Dehydrogenase (C0022917)

Definition (NCI_NCI-GLOSS) One of a group of enzymes found in the blood and other body tissues and involved in energy production in cells. An increased amount of lactate dehydrogenase in the blood may be a sign of tissue damage and some types of cancer or other diseases.
Definition (NCI) A family of homotetrameric cytoplasmic enzymes involved in the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.
Definition (CSP) do not confuse with EC 1.1.2.3, EC 1.1.2.4, or EC 1.1.2.5, lactate dehydrogenase (cytochrome).
Definition (MSH) A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.
Concepts Amino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSH D007770
SnomedCT 259319003, 70012008
LNC LP15033-1, MTHU002348
English Dehydrogenase, Lactate, Lactate Dehydrogenase, (S)-Lactate:NAD+ oxidoreductase, LACTATE DEHYDROGENASE L, L lactate dehydrogenase, lactate dehydrogenases, L-Lactate Dehydrogenase [Chemical/Ingredient], dehydrogenase lactate, l-lactate dehydrogenase, lactate dehydrogenase, LDH, lactic acid dehydrogenase, Dehydrogenase, L-Lactate, L Lactate Dehydrogenase, L-Lactate Dehydrogenase, Lactate dehydrogenase, L-Lactate dehydrogenase, Lactic acid dehydrogenase, LD - Lactate dehydrogenase, LDH - Lactate dehydrogenase, L-Lactate dehydrogenase (substance), Lactate dehydrogenase (substance), L-(+)-Lactate Dehydrogenase, L-Lactic Acid Dehydrogenase, Lactic Acid Dehydrogenase, NAD-Lactate Dehydrogenase, EC 1.1.1.27
Swedish L-laktatdehydrogenas
Czech dehydrogenasa kyseliny mléčné, laktátdehydrogenasa, L-laktátdehydrogenasa
Finnish L-laktaattidehydrogenaasi
Russian LAKTATDEGIDROGENAZY IZOFERMENTY, DEGIDROGENAZA MOLOCHNOI KISLOTY, L-LAKTATDEGIDROGENAZA, LAKTATDEGIDROGENAZA, IZOFERMENTY LAKTATDEGIDROGENAZY, L-ЛАКТАТДЕГИДРОГЕНАЗА, ДЕГИДРОГЕНАЗА МОЛОЧНОЙ КИСЛОТЫ, ИЗОФЕРМЕНТЫ ЛАКТАТДЕГИДРОГЕНАЗЫ, ЛАКТАТДЕГИДРОГЕНАЗА, ЛАКТАТДЕГИДРОГЕНАЗЫ ИЗОФЕРМЕНТЫ
Japanese ラクテートデヒドロゲナーゼ, L-乳酸脱水素酵素, 乳酸デヒドロゲナーゼ, 乳酸脱水素酵素, L-乳酸デヒドロゲナーゼ
Croatian L-LAKTAT DEHIDROGENAZA
Polish Dehydrogenaza mleczanowa, Dehydrogenaza L-mleczanowa, Mleczanowa reduktaza cytochromowa
Spanish LDH, L - lactato deshidrogenasa (sustancia), L - lactato deshidrogenasa, lactato deshidrogenasa, láctico deshidrogenasa (sustancia), láctico deshidrogenasa, ácido láctico deshidrogenasa, Lactato Deshidrogenasa, L-Lactato Deshidrogenasa
French Lactate déshydrogénase, L-Lactate dehydrogenase, L-Lactate déshydrogénase
German Lactat-Cytochrom-Reductase, Lactatdehydrogenase-Isoenzyme, Lactatdehydrogenase-Isozyme, Lactatdehydrogenase
Italian L-lattato deidrogenasi
Portuguese Lactato Desidrogenase, L-Lactato Desidrogenase