II. Precautions: Red Flags may suggest serious underlying conditions

III. Precautions: Red Flags in Dyspepsia

  1. Age of onset cut-off
    1. Current age cut-off: age over 45-56 years
    2. Recent literature suggests adjusting based on gender
      1. Age over 35 years in men
      2. Age over 56 years in women
      3. Marmo (2005) Am J Gastroenterol 100:784-91 [PubMed]
  2. Dysphagia
  3. Anorexia or early satiety
  4. Persistent Vomiting
  5. Jaundice
  6. Palpable abdominal mass
  7. Family History of Gastric Cancer
    1. More common in non-caucasian (esp. black patients)
  8. Prior Peptic Ulcer Disease history
  9. Unexplained weight loss
    1. Weight loss more than 3 kg or 6.5 pounds
    2. Weight loss >10% of body weight
  10. Signs of significant Gastrointestinal Bleeding
    1. Anemia
    2. Rectal bleeding or Melena

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