II. Indication

  1. Adjunct to Open Angle Glaucoma therapy

III. Mechanism: Intraocular Epinephrine

  1. Decreases aqueous outflow resistance
  2. Decreases aqueous production

IV. Preparations

  1. Dipivefrin (Propine) 1 drop bid

V. Adverse Effects (If absorbed)

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Ontology: Dipivefrin (C0058415)

Definition (NCI) An ester prodrug of epinephrine, with sympathomimetic activity. Due to its lipophilicity, dipivefrin penetrates more easily to the anterior chamber of the eye and is hydrolyzed to epinephrine, when applied locally. Epinephrine, an adrenergic agonist, enhances the outflow of aqueous humor and decreases the production of aqueous humor by vasoconstriction. The overall result is a reduction in intraocular pressure.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C015173
SnomedCT 73647000, 37013008, 372830005
English dipivaloylepinephrine, dipivalyl epinephrine, dipivefrin, Propanoic acid, 2,2-dimethyl-, 4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylene ester, (+-)-, DPE - Dipivefrin, adrenaline dipivalate, dipivefrin [Chemical/Ingredient], DPE, DPE - dipivalyl epinephrine, dipivefrine, Dipivalyl epinephrine, Dipivefrine, Dipivalyl adrenaline, Dipivefrin (product), Dipivefrin (substance), Dipivefrin, DIPIVEFRIN
Spanish dipivalil epinefrina, dipivefrina (producto), dipivefrina (sustancia), dipivefrina

Ontology: Propine (C0138647)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C015173
English Propine, propine, Propine brand, Diopine, Allergan brand of dipivefrin hydrochloride