II. Pharmacokinetics: Carbon Monoxide half-life

  1. Room air
    1. Carbon Monoxide Half-Life: 320 min
  2. Non-rebreather at 100% FIO2
    1. Carbon Monoxide Half-Life: 80 min
  3. Hyperbaric oxygen at 3 Atmospheres
    1. Carbon Monoxide Half-Life: 23 min

III. Causes: Increased

IV. Findings: Carboxyhemoglobin level

  1. Carboxyhemoglobin: 10%
    1. Frontal Headache
  2. Carboxyhemoglobin: 20%
    1. Throbbing Headache
    2. Dyspnea on exertion
  3. Carboxyhemoglobin: 30%
    1. Impaired judgment
    2. Nausea or Vomiting
    3. Dizziness
    4. Visual disturbance
    5. Fatigue
  4. Carboxyhemoglobin: 40%
    1. Confusion
    2. Syncope
  5. Carboxyhemoglobin: 50%
    1. Coma
    2. Seizures
  6. Carboxyhemoglobin: 60%
    1. Hypotension
    2. Respiratory failure
  7. Carboxyhemoglobin: 70%
    1. Death

V. References

  1. Rothrock (2009) Adult Emergency Pocketbook, Tarascon, p. 170

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Ontology: Carboxyhemoglobin (C0007061)

Definition (NCI) Hemoglobin where the heme group has formed a stable complex with carbon monoxide (CO). This complex is produced after CO has been inhaled or as a byproduct of hemoglobin, protoporphyrin or dichloromethane catabolism. The heme-CO complex is approximately 200 times more stable than heme-oxygen complexes. Thus, high levels of carboxyhemoglobin in the circulation can lead to tissue hypoxia and death.
Definition (CSP) hemoglobin in which the sites usually bound to oxygen are bound to carbon monoxide.
Concepts Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116)
MSH D002263
SnomedCT 62576004, 116824006
LNC LP21418-6, LP16344-1, MTHU009138
English Carbomonoxyhemoglobin, Carbonmonoxyhemoglobin, Carbonylhemoglobin, Carboxyhemoglobin, Hemoglobins, carbonyl-, Carbonyl hemoglobin, Carbonyl haemoglobin, Carboxyhemoglobin [Chemical/Ingredient], carboxyhaemoglobin, carboxyhemoglobin, carboxyhemoglobins, hemoglobin carbon monoxide, Carbonyl hemoglobin (substance), COHb, Carbon monoxide hemoglobin, Carbon monoxide haemoglobin, Carboxyhaemoglobin, HbCO - Carboxyhaemoglobin, HbCO - Carboxyhemoglobin, Carboxyhemoglobin (substance), COHbon monoxide hemoglobin
Swedish Kolmonoxidhemoglobin
Czech karboxyhemoglobin
Finnish Karboksihemoglobiini
Italian Carbomonossi emoglobina, Carbon-monossi emoglobina, Carbonilemoglobina, Carbossiemoglobina
French Carbonylhémoglobine, Carboxyhémoglobine, Hémoglobine oxycarbonée
Polish Karboksyhemoglobina
Japanese 一酸化炭素血色素, 一酸化炭素ヘモグロビン, カルボキシヘモグロビン, カルボニルヘモグロビン
Spanish carbonil hemoglobina, carbonil hemoglobina (sustancia), HbCO, carboxihemoglobina (sustancia), carboxihemoglobina, hemoglobina de monóxido de carbono, Carboxihemoglobina, Carbomonoxihemoglobina
German Carbomonoxyhämoglobin, Carboxyhämoglobin
Portuguese Carbomonoxihemoglobina, Carboxihemoglobina