II. Pathophysiology

  1. Associated with topical agent use >5-7 days
  2. Tachyphylaxis associated with medications
    1. Nasal Decongestants (Afrin, Neo-Synephrine)
    2. Nasal spray preservative Benzalkonium chloride
  3. Other associated medications
    1. Reserpine
    2. Oral Contraceptive pills
    3. Inderal
    4. Aldomet

III. Symptoms

  1. Rebound nasal Congestion after nasal Decongestant

IV. Signs

  1. Fiery red edema at nasal mucosa

V. Management

  1. Intranasal Steroid (e.g. Vancenase)
  2. Withdrawal of nasal Decongestant

VI. Prevention

  1. Avoid prolonged use of nasal Decongestants

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