II. Causes: Medications

  1. Analgesics
    1. Aspirin (>2.7 g/day) and other Salicylates
    2. NSAIDs
    3. Acetaminophen
    4. Sulfasalazine (Azulfidine)
  2. Antibiotics
    1. Aminoglycosides
      1. Starts with Tinnitus and rapidly progresses to Hearing Loss
      2. Ototoxicity symptoms are permanent if last >2-3 weeks after stopping the Aminoglycoside
    2. Streptomycin
    3. Vancomycin
    4. Erythromycin (dose >2 g/day) and other Macrolides
    5. Chloramphenicol
    6. Doxycycline or Minocycline (transient vestibular toxicity)
    7. Imipenem-Cilastin (Primaxin)
    8. Linezolid (Zyvox)
    9. Sulfonamide
    10. Fluoroquinolones
    11. Voriconazole
    12. Amphoteracin B
    13. Ganciclovir
    14. Ribavirin
  3. Loop Diuretics (especially at high dose with rapid infusion)
    1. Ethacrynic Acid
    2. Furosemide (Lasix)
  4. Antineoplastic
    1. Cisplatin
    2. Vincristine and other Vinca Alkaloids
    3. Nitrogen Mustard
    4. Methotrexate
    5. Etoposide
    6. Protein kinase inhibitor
  5. Other medications
    1. Quinine
    2. Chloroquine
    3. Sildenafil (Viagra)
    4. Caffeine
    5. Atorvastatin (Lipitor)
    6. Bupropion (Wellbutrin)
    7. Risedronate (Actonel)
    8. Verenicline (Chantix)

III. Causes: Ilicit Drugs and Poisonings

  1. Heavy metal Poisoning
    1. Mercury Poisoning
    2. Lead Poisoning
  2. Occupational exposures
    1. Toluene
    2. Styrene
  3. Ilicit Drugs
    1. Ecstasy

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Ontology: Ototoxicity (C0235280)

Concepts Injury or Poisoning (T037)
SnomedCT 9062008
English OTOTOXICITY, ototoxicity, Ototoxicity, Ototoxicity (disorder), Ototoxicity, NOS
Italian Ototossicità
Japanese 聴器毒性, チョウキドクセイ
Portuguese OTOTOXICIDADE, Ototoxicidade
Spanish OTOTOXICIDAD, ototoxicidad (trastorno), ototoxicidad, Ototoxicidad
French OTOTOXICITE, Ototoxicité
German OTOTOXIZITAET, Ototoxizitaet
Czech Ototoxicita
Hungarian ototoxicitas
Dutch ototoxiciteit