II. Indications

  1. Severe, airway compromising Angioedema
    1. Hereditary Angioedema (treatment of choice)
    2. ACE InhibitorAngioedema (may be effective, off label use)

III. Mechanism

  1. Selective Bradykinin B2 Receptor Antagonist

IV. Dosing

  1. Initial Dose: 30 mg SQ
  2. Second Dose: 30 mg SQ at 6 hours after first if inadequate response to the initial dose
  3. Maximum: 90 mg total daily dose
  4. Cost: $10,000 per 30 mg dose

V. Adverse Effects

  1. Local skin reaction (97%)
  2. Dizziness (3%)
  3. Fever (4%)

VI. References

  1. (2015) Lexicomp, accessed online 4/9/2015
  2. Bas (2015) N Engl J Med 372(5):418-25 +PMID:25629740 [PubMed]

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