II. Epidemiology

  1. Women account for 75% of Autoimmunity
  2. Age of onset is most common in young adult women

III. Mechanism

  1. Autoantibody, T-Cell mediated self tissue destruction
  2. Predisposing factors
    1. Autoimmunity increases with age: lower self tolerance
    2. Genetic predisposition
  3. Protective factors
    1. Autoimmunity less common where high antigen exposure
    2. Protective exposures in first year of life
      1. Eating dirt
      2. Living on a farm
      3. House pet
      4. Day care
    3. References
      1. Weiss (2002) N Engl J Med 347:930 [PubMed]

IV. Associated Conditions: Dermatologic Autoimmune Conditions

V. Associated Conditions: Endocrine Autoimmune Conditions

VI. Associated Conditions: Gastrointestinal Autoimmune Conditions

VII. Associated Conditions: Hematologic Autoimmune Conditions

IX. Associated Conditions: Neurologic Autoimmune Conditions

X. Associated Conditions: Vascular Autoimmune Conditions

XI. References

  1. Zuber (2003) AAFP Board Review, Seattle

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Ontology: Autoimmunity (C0004368)

Definition (NCI) Autoimmune Status; the state of a person's health in regard to autoimmune disease or antibody presence.
Definition (MSH) Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES.
Definition (CSP) developmentally complex, not necessarily pathological, possibly pervasive, cell or humoral immune system reactivity toward autologous (self) antigens; do not confuse with AUTOIMMUNE DISORDER.
Concepts Pathologic Function (T046)
MSH D015551
SnomedCT 4301008
English Autoimmunities, Autoimmunity, self recognition (immune), autoimmunity, autoimmunities, Autoimmune state (finding), Autoimmune state, Autoimmune state, NOS, Autoimmunity, NOS, Autoimmune Status
Swedish Autoimmunitet
Czech autoimunita
Finnish Autoimmuniteetti
French Auto-immunité, Autoimmunité
Russian AUTOIMMUNITET, АУТОИММУНИТЕТ
Spanish estado autoinmunitario (hallazgo), estado autoinmune (hallazgo), estado autoinmunitario, estado autoinmune, autoinmunidad, Autoinmunidad
Portuguese Autoimunidade, Reação Autoimune
Croatian AUTOIMUNOST
Polish Odpowiedź autoimmunizacyjna, Autoodporność, Odpowiedź autoodpornościowa
Norwegian Autoimmunitet
German Autoimmunisierung
Dutch Auto-immuniteit
Italian Autoimmunità