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Hemoglobin A1CAka: Glycosylated Hemoglobin, HBA1C, HgbA1c

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  1. Epidemiology
    1. Hemoglobin A1C may be important measure in non-diabetic
    2. Hemoglobin A1C associated mortality (contrast with <5)
      1. Relative risk of Hemoglobin A1C 5.0 to 5.4
        1. All cause mortality: 1.41
        2. Cardiovascular mortality: 2.53
      2. Relative risk of Hemoglobin A1C 5.4 to 6.9
        1. All cause mortality: 2.07
        2. Cardiovascular mortality: 2.46
      3. Relative risk of Hemoglobin A1C 7.0 or higher
        1. All cause mortality: 2.64
        2. Cardiovascular mortality: 5.04
      4. References
        1. Khaw (2001) BMJ 322:15
  2. Background
    1. Glycosylated Hemoglobin is not equivalent to A1C
      1. Hemoglobin A1C is 70% total glycosylated Hemoglobin
  3. Approximating Serum Glucose
    1. Hemoglobin A1C of 6% represents mean glucose of 130
    2. Each 1% increase in A1C, glucose increases 30
  4. Interpretation: Correlation to Mean Serum Glucose
    1. Hemoglobin A1C: 5.5% represents mean glucose of 100
    2. Hemoglobin A1C: 7.0% represents mean glucose of 150
    3. Hemoglobin A1C: 8.0% represents mean glucose of 180
    4. Hemoglobin A1C: 9.0% represents mean glucose of 220
    5. Hemoglobin A1C: 10.0% represents mean glucose of 250
    6. Hemoglobin A1C: 11.5% represents mean glucose of 300
    7. Hemoglobin A1C: 13.0% represents mean glucose of 350
  5. Interpretation: Fasting vs post-prandial hyperglycemia
    1. Hemoglobin A1C <7.3%:
      1. Postprandial Glucose: 30%
      2. Fasting Glucose: 70%
    2. Hemoglobin A1C 7.3-8.4%
      1. Postprandial Glucose: 50%
      2. Fasting Glucose: 50%
    3. Hemoglobin A1C 8.5-9.2%
      1. Postprandial Glucose: 55%
      2. Fasting Glucose: 45%
    4. Hemoglobin A1C 9.3-10.2%
      1. Postprandial Glucose: 60%
      2. Fasting Glucose: 40%
    5. Hemoglobin A1C >10.2%
      1. Postprandial Glucose: 70%
      2. Fasting Glucose: 30%
    6. References
      1. Monnler (2003) Diabetes Care 26:881
  6. Interpretation: Diagnosis of Diabetes Mellitus
    1. Hemoglobin A1C <5.2%: No Diabetes Mellitus
      1. Test Sensitivity: 100%
    2. Hemoglobin A1C >6%: Diabetes Mellitus
      1. Test Specificity: 100%

Hemoglobin, Glycosylated (C0017853)

ConceptsAmino Acid, Peptide, or Protein (T116) , Biologically Active Substance (T123)
MSHD006442
EnglishGlycated haemoglobin, Glycated hemoglobin, Glycated Hemoglobins, Glycosylated haemoglobin, Glycosylated Hb, Glycosylated Hemoglobin, Hemoglobin.glycated
Spanishglucohemoglobina
Parent ConceptsHemoglobin (C0019046)
SourcesAOD, CSP, LNC, MSH, MTH, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Glycosylated hemoglobin A (C0019018)

Definition (MSH)Minor hemoglobin components of human erythrocytes designated A1a, A1b, and A1c. Hemoglobin A1c is most important since its sugar moiety is glucose covalently bound to the terminal amino acid of the beta chain. Since normal glycohemoglobin concentrations exclude marked blood glucose fluctuations over the preceding three to four weeks, the concentration of glycosylated hemoglobin A is a more reliable index of the blood sugar average over a long period of time.
ConceptsAmino Acid, Peptide, or Protein (T116) , Biologically Active Substance (T123)
MSHD006442
EnglishGlycohemoglobin A, Glycosylated haemoglobin A, Glycosylated Hemoglobin A, Haemoglobin A1c, Hb A1, Hb A1a+b, Hb A1c, HB AC 01, HBA 01, HBA GLYCOSYLATED, HbA<sub>1c</sub>, HbA>1c<, HbA1, HbA1 - Glycated haemoglobin, HbA1 - Glycated hemoglobin, HbA1c, Hemoglobin A1c, HEMOGLOBIN AA 01
Spanishhemoglobina A glucosilada, hemoglobina A1c, hemoglobina glucosilada
Parent ConceptsGlycosides (C0017977), Hemoglobin A (C0019016), Glycosylated hemoglobin A (C0019018), Hemoglobin (C0019046), Duplicate concept (C1274013)
SourcesCSP, LNC, MSH, MTH, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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