II. Epidemiology

  1. Incidence: Rare (0.22 per Million persons in U.S.)

III. Pathophysiology

IV. Predisposing factors

  1. Cold exposure
  2. Trauma
  3. Infection
  4. Narcotics

V. Signs

  1. See Hypothyroidism
  2. Hypothermic stuporous state
  3. Respiratory depression with hypercarbia
  4. Pleural Effusion
  5. Percardial effusion
  6. Megacolon
  7. Hemodynamic instability

VI. Labs

VII. Management

  1. Medical emergency with high mortality
  2. Endocrinology Consultation
  3. ICU admission
  4. Ventilatory and hemodynamic support
  5. Anticipate electrolyte abnormalities (e.g. Hyponatremia)
  6. Consider Corticosteroids

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Ontology: Myxedema coma (C0238298)

Concepts Disease or Syndrome (T047)
ICD10 E03.5
SnomedCT 190292006, 21263006
Italian Coma da mixedema
French Coma de myxoedème, Coma myxoedèmateux
Portuguese Coma de mixedema, Coma mixedematoso
Spanish Coma por mixedema, coma hipotiroideo (trastorno), coma hipotiroideo, coma mixedematoso, Coma mixedematoso
Japanese 粘液水腫性昏睡, ネンエキスイシュセイコンスイ
English myxedema coma, myxedema coma (diagnosis), Myxoedema coma (disorder), Myxedema coma, Hypothyroid coma, Myxoedema coma, Myxedema coma (disorder), coma; myxedema, myxedema; coma
Czech Myxedémové kóma
Korean 점액수종 혼수
Hungarian Mixödemás kóma, Mixödémás kóma
Dutch coma; myxoedeem, myxoedeem; coma, Myxoedeemcoma, myxoedeem coma
German Myxoedemkoma