II. Background

  1. Discovered in 1940's when investigating antibiotics

III. Mechanism

  1. Stimulates Potassium channel closure on pancreatic beta cell surface
  2. Results in Insulin release

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Ontology: Sulfonylurea Compounds (C0038766)

Definition (CSP) compounds of the type R-SO2-NHCONH-; when R=Ph, these are a group of hypoglycemic agents which enhance insulin secretion by beta cells and insulin sensitivity in target tissue, and so are effective in type II (noninsulin-dependent) diabetes mellitus.
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D013453
SnomedCT 273950002, 34012005, 372711004, 259552008
LNC LP18787-9, MTHU005387
English Compounds, Sulfonylurea, SULFONYLUREA CPDS, Sulfonylurea and its derivs, Sulphonylurea and its derivs, sulfonylureas (medication), sulfonylureas, sulfonylurea compounds, oral hypoglycemics sulfonylureas, Sulfonylurea Compounds, Sulfonylurea Compounds [Chemical/Ingredient], sulphonylureas, sulphonylurea, Sulfonylurea, Sulfonylurea compounds, Sulfonylurea product, Sulphonylurea, Sulphonylurea compounds, Sulphonylurea product, Sulfonylurea and its derivatives, Sulphonylurea and its derivatives, Sulfonylurea (product), Sulfonylurea (substance), Sulfonylurea and its derivatives (substance), sulfonylurea, Sulfonylurea, NOS, Sulfonylurea [dup] (substance), Sulfonylureas
Swedish Sulfonylureaföreningar
Czech sulfonylmočovinové sloučeniny, glibornurid, sulfonylureové deriváty, sulfonylureové sloučeniny
Finnish Sulfonyyliurea
Russian SUL'FONILMOCHEVINY SOEDINENIIA, GLIBORNURID, ГЛИБОРНУРИД, СУЛЬФОНИЛМОЧЕВИНЫ СОЕДИНЕНИЯ
Croatian SULFONILUREJA, SPOJEVI
Polish Sulfonylomocznika związki
Portuguese Compostos de Sulfonilureia
Spanish sulfonilurea (producto), sulfonilurea (sustancia), sulfonilurea y derivados (sustancia), sulfonilurea y derivados, sulfonilurea, Compuestos de Sulfonilurea
French Sulfonylurées
German Sulfonylharnstoffverbindungen
Italian Derivati della solfonilurea