II. Mechanism

  1. Systemic Corticosteroid
  2. Expands intravascular volume

III. Indications

IV. Adverse Effects

  1. Volume overload
  2. Hypokalemia
  3. Hypomagnesemia
  4. Headache
  5. Edema
  6. Weight gain
  7. Supine Hypertension

V. References

  1. (2003) Lexi-comp Drug Database

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Cost: Medications

fludrocortisone (on 8/17/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
FLUDROCORTISONE 0.1 MG TABLET Generic $0.40 each

Ontology: Fludrocortisone (C0016280)

Definition (NCI) A synthetic corticosteroid with antiinflammatory and antiallergic properties. Fludrocortisone is a mineralocorticoid receptor and glucocorticoid receptor agonist that binds to cytoplasmic receptors, translocates to the nucleus and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2. This prevents the release of arachidonic acid, a precursor to prostaglandins and leukotrienes, both important mediators in the pro-inflammatory response mechanism. In addition, this agent exerts its mineralocorticoid effect on the distal tubules and collecting ducts of the kidney by inducing permease, an enzyme that regulates Na+ permeability in cells, thereby enhancing Na+ reabsorption and water retention as well as increasing K+, H+ excretion.
Definition (NCI_NCI-GLOSS) A synthetic corticosteroid. It is used to replace steroid hormones normally produced by the adrenal gland.
Definition (MSH) A synthetic mineralocorticoid with anti-inflammatory activity.
Concepts Pharmacologic Substance (T121) , Hormone (T125) , Steroid (T110)
MSH D005438
SnomedCT 116586002, 89192008
LNC LP35868-6, MTHU018755
English 9 alpha-Fluorohydrocortisone, 9-Fluorocortisol, 9-Fluorohydrocortisone, Fludrocortisone, 9 Fluorocortisol, 9 Fluorohydrocortisone, 9 alpha Fluorohydrocortisone, fludrocortisone, Pregn-4-ene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11beta)-, 9 Fluoro 17 Hydroxycortisone, 9 alpha Fludrohydrocortisone, 9 alpha Fluoro 17 Hydroxycorticosterone, 9 alpha-Fluoro-17-Hydroxycorticosterone, 9-Fluoro-17-Hydroxycortisone, FLUOROCORTISOL 09, Fludrocortisone [Chemical/Ingredient], 9-fluorohydrocortisone, FLUDROCORTISONE, Fludrocortisone preparation, Fludrocortisone (substance), Fludrocortisone preparation (product), Fludrocortisone preparation (substance)
Swedish Fludrokortison
Czech fludrokortison
Finnish Fludrokortisoni
Spanish fludrocortisona (producto), preparado con fludrocortisona (producto), preparado con fludrocortisona, fludrocortisona (sustancia), fludrocortisona, preparado de fludrocortisona (producto), preparado de fludrocortisona (sustancia), preparado de fludrocortisona, 9-Fluorocortisol, Fludrocortisona
Italian 9 alfa-Fluoro-17-idrossicortisone, 9-Fludro-idrocortisone, 9 alfa Fludro-idrocortisone, 9-Fluoro-17-idrossicortisone, 9-Fluorocortisolo, 9-Fluoro-17-idrocortisone, Fludrocortisone
German FLUORCORTISOL 09, 9-Fluorcortisol, Fludrocortison
Polish Fludrokortyzon
Japanese 酢酸フルドロコルチゾン, フルドロコルチゾン, 9-フルオロコーチゾル, フロリネフ
French Fludrocortisone
Portuguese Fludrocortisona, 9-Fluorcortisol

Ontology: Florinef (C0060486)

Concepts Pharmacologic Substance (T121) , Steroid (T110)
MSH C034635
English Florinef Acetate, Florinef, florinef, florinef acetate, acetate florinef, Florinef acetate, Bristol-Myers Squibb brand of fludrocortisone 21-acetate, Monarch brand of fludrocortisone 21-acetate, Shire brand of fludrocortisone 21-acetate