II. Measurement

  1. Measures responsiveness of pituitary to TRH

III. Protocol

  1. Administer TRH 500 ug
  2. Measure Thyroid Stimulating Hormone (TSH) at 30-60 min

IV. Interpretation: TSH

  1. Normal Response
    1. TSH rises 2-4x baseline
  2. Hyperthyroidism
    1. Low TSH with suppressed response to TRH
  3. Hypothyroidism
    1. High TSH with exaggerated TRH response

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Ontology: Thyrotropin-Releasing Hormone (C0040162)

Definition (NCI) Expressed (highest) in the medial hypothalamic paraventricular nuclei and median eminence by human TRH Gene, 242-aa 27-kDa (precursor) (prepro-)Thyrotropin-Releasing Hormone is a major regulator of TSH biosynthesis and release in the anterior pituitary gland and neurotransmitter/neuromodulator in the central and peripheral nervous systems. (NCI)
Definition (CSP) tripeptide hormone elaborated by the median eminence of the hypothalamus which stimulates release of thyrotropin from the anterior pituitary gland.
Definition (MSH) A tripeptide that stimulates the release of THYROTROPIN and PROLACTIN. It is synthesized by the neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, TRH (was called TRF) stimulates the release of TSH and PRL from the ANTERIOR PITUITARY GLAND.
Concepts Amino Acid, Peptide, or Protein (T116) , Hormone (T125) , Pharmacologic Substance (T121)
MSH D013973
SnomedCT 29361008, 73805002, 10534002, 412495007, 412496008, 412494006
LNC LP32535-4, LP62881-5, MTHU025741
English Thyrotropin-Releasing Hormone, TRF - Protirelin, TRH - Protirelin, Thyrotropin Releasing Factor, Thyrotropin-Releasing Factor, pyroGlu-His-Pro-NH2 (or 5-oxo-L-prolyl-L-histidyl-L-prolinamide), TRH-Thyrotrophin rel horm, thyrotropin releasing hormone, protirelin, protirelin (discontinued) (medication), protirelin (discontinued), thyrotropin-releasing hormone, thyrotropin RH, hormones protirelin (discontinued), Thyrotropin-releasing factor, Thyrotropin-Releasing Hormone [Chemical/Ingredient], thyrotrophin releasing hormone, trh, thyrotropin releasing hormone (TRH), PROTIRELIN, Protirelin preparation (product), Protirelin preparation, Thyrotropin releasing hormone preparation, TRF, TRH, Thyrotrophin-releasing hormone, Thyrotropin releasing factor, Thyrotropin releasing hormone, TRH - Thyrotrophin releasing hormone, Thyrotrophin releasing hormone, Thyrotropin releasing factor (substance), Thyrotropin releasing hormone preparation (product), Protirelin preparation -RETIRED-, Thyrotropin releasing hormone preparation (substance), Protirelin (product), Protirelin (substance), Thyrotropin releasing factor agent (substance), Thyrotropin releasing factor agent, Thyrotropin Releasing Hormone, Protirelin
Portuguese Hormônio Liberador de Tireotropina, Hormônio Liberador de Tirotropina, Hormônio Liberador de Tirotrofina, Protirelina
German Thyreotropin-Releasing-Hormon, Prolactin-Releasing-Hormon, Protirelin, Thyreotropin-Releasing-Faktor, TRH (Thyreotropin-Releasing-Hormon), Thyreotropin-Releasing Hormon
French Thyrolibérine, Hormone de libération de la thyrotropine, Hormone de libération de la thyréostimuline, Facteur de libération de la thyrotropine, Facteur de libération de la thyréostimuline, Hormone de libération de la thyréotropine, TRF (Thyrotropin-Releasing Factor), Thyréolibérine, Protireline, Protyreline, Pyr-His-ProNH2, TRH (Thyrotropin-Releasing Hormone)
Swedish Tyreotropinfrisättande hormon
Czech hormon uvolňující thyreotropin, hormon uvolňující tyreotropin, protirelin, tyreoliberin, thyreoliberin
Finnish Tyreoliberiini
Russian TIROLIBERIN, TIROTROPIN-RILIZING-GORMON, TIREOTROPIN-RILIZING-GORMON, PROTIRELIN, TIREOTROPNYI GORMON-OSVOBOZHDAIUSHCHII FAKTOR, ПРОТИРЕЛИН, ТИРЕОТРОПИН-РИЛИЗИНГ-ГОРМОН, ТИРЕОТРОПНЫЙ ГОРМОН-ОСВОБОЖДАЮЩИЙ ФАКТОР, ТИРОЛИБЕРИН, ТИРОТРОПИН-РИЛИЗИНГ-ГОРМОН
Japanese オリストン, チロリベリン, 酒石酸プロチレリン, ボグニン, プロチレリン酒石酸塩, シンプロチン, ヒシダリン, ヒルロック, 甲状腺刺激ホルモン放出因子, プロチレリン酒石酸塩水和物, プロチレリン, ヒルトニン, アルヒルト, 甲状腺刺激ホルモン放出ホルモン, チロトロピン放出ホルモン, サイロトロピン放出ホルモン
Spanish hormona liberadora de tirotrofina, hormona liberadora de tirotrofina (producto), preparado de hormona liberadora de tirotrofina (producto), preparado de hormona liberadora de tirotrofina, preparado de protirrelina, preparado de protirrelina-RETIRADO-, preparado de protirrelina-RETIRADO- (concepto no activo), factor liberador de TSH, factor liberador de tirotrofina (sustancia), factor liberador de tirotrofina, hormona liberadora de TSH, preparado de TRH, preparado de hormona liberadora de tirotrofina (sustancia), preparado de tiroliberina, agente con factor liberador de tirotrofina (sustancia), agente con factor liberador de tirotrofina, protirelina (producto), protirelina (sustancia), protirelina, Hormona Liberadora de Tirotropina, Protirelina
Italian Tiroliberina, Protirelina, Ormone di rilascio della tirotropina, Ormone rilasciante la tirotropina
Croatian HORMON KOJI OSLOBAĐA TIREOTROPIN
Polish Tyreoliberyna, Hormon uwalniający tyreotropinę
Norwegian Protirelin, TRH, Tyreoliberin, Tyreotropinfrigjørende hormon