II. Causes

  1. Excessive Melanin deposition: Addison's Disease
  2. Excessive Melanocytes: Phototoxic Drug Reaction

III. Signs

  1. Diffuse brown discoloration of skin
  2. Oral Mucosa pigmentation
  3. Accentuated areas
    1. Palmar creases
    2. Recent scars
    3. Pressure points at elbow, knee, and knuckles

IV. Differential Diagnosis

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Ontology: Melanosis (C0025209)

Definition (MSH) Disorders of increased melanin pigmentation that develop without preceding inflammatory disease.
Concepts Disease or Syndrome (T047)
MSH D008548
SnomedCT 267870007, 156438005, 48010006, 239082002, 414662006
English Melanoses, Melanosis, Melanism, MELANOSIS, Melanosis [Disease/Finding], melanism, melanosis, melanose, Melanosis (morphologic abnormality), Melanosis, NOS, Melanosis (disorder)
French MELANOSE, Mélanose, Mélanisme
Portuguese MELANOSE, Melanose, Melanismo
Spanish MELANOSIS, Melanosis, melanismo, melanosis (anomalía morfológica), melanosis, Melanosis (trastorno), Melanismo
German MELANOSE, Melanosis, Melanismus, Melanose
Swedish Melanos
Japanese メラノーシス, メラニン沈着症, メラニン沈着, 肝斑, メラノーシス, 黒皮症, そばかす, 黒色症, 肝斑(カンハン)
Czech melanóza, Melanóza
Finnish Melanoosi
Russian MELANODERMIIA, MELANOZ, KHLOAZMA, PIGMENTNYE PIATNA NA KOZHE, МЕЛАНОДЕРМИЯ, МЕЛАНОЗ, ПИГМЕНТНЫЕ ПЯТНА НА КОЖЕ, ХЛОАЗМА
Italian Melanismo, Melanosi
Croatian MELANOZA
Polish Melanoza
Hungarian Melanosis
Norwegian Melanose
Dutch melanosis, Melanisme, Melanosis