II. Mechanism of Drug-Induced Pemphigus

  1. Sulfhydryl groups lyse disulfide bonds
  2. Results in Blister formation

III. Causes of Drug-Induced Pemphigus

IV. Signs of Drug-Induced Pemphigus

  1. Pemphigus follows medication use of >2 month duration
  2. Similar to Superficial Pemphigus (Pemphigus Foliaceus)
    1. Most cases are mild

V. Differential Diagnosis of Drug-Induced Pemphigus

  1. Erythema Multiforme
  2. Drug-Triggered Pemphigus (unmasks Pemphigus Vulgaris)
    1. Rifampin
    2. Penicillin
    3. Cephalexin
    4. Progesterone
    5. Gold
    6. Piroxicam
    7. Phenobarbital

VI. Course

  1. Drug-Induced Pemphigus
    1. Remits with stopping medication in 40-50% of cases
    2. May follow severe course in some cases
  2. Drug-Triggered Pemphigus
    1. Does not remit
    2. Follows course of Pemphigus Vulgaris

VII. References

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Ontology: Drug-induced pemphigus (C0451938)

Concepts Pathologic Function (T046)
ICD10 L10.5
SnomedCT 200907003
German Arzneimittelinduzierter Pemphigus
Korean 약물유발성 천포창
English drug-induced pemphigus, pemphigus drug-induced, drug-induced pemphigus (diagnosis), Drug-induced pemphigus, Drug-induced pemphigus (disorder), drug; pemphigus, pemphigus; drug-induced
Dutch geneesmiddel; pemphigus, pemphigus; geneesmiddel-geïnduceerd, Door geneesmiddel geïnduceerde pemphigus
Spanish pénfigo medicamentoso (trastorno), pénfigo medicamentoso