II. Pathophysiology

  1. Autoimmune skin disorder
  2. Associated with HLA-DR3, and HLA-DR4

III. Associated conditions

IV. Signs

  1. Vesicles and bullae form on Abdomen, extremities

V. Management

  1. Increased antepartum observation
  2. Oral Antihistamines
  3. Topical Corticosteroids
  4. Systemic Corticosteroids in severe cases

VI. Complications

  1. Preterm delivery
  2. Small for Gestational Age infant

VII. Course

  1. Onset in second-half of pregnancy
  2. Improves in late pregnancy
  3. May be exacerbated in early postpartum period
  4. May recur in future pregnancies

Images: Related links to external sites (from Bing)

Related Studies (from Trip Database) Open in New Window

Ontology: Pemphigoid Gestationis (C0019343)

Definition (NCI) An autoimmune bullous dermatitis that develops during pregnancy, most often during the second and third trimesters.(NICHD)
Definition (MSH) An itching, autoimmune, bullous SKIN disease that occurs during the last two trimesters of PREGNANCY and PUERPERIUM. It also affects non-pregnant females with tissue of PLACENTA origin, such as CHORIOCARCINOMA; or HYDATIDIFORM MOLE. It exhibits antigenic and clinical similarity to bullous pemphigoid (PEMPHIGOID, BULLOUS). This disease does not involve herpes viruses (old name, herpes gestationis).
Concepts Pathologic Function (T046)
MSH D006559
ICD10 O26.4 , O26.40
SnomedCT 199131000, 270959002, 199126002, 156129002, 86081009
LNC LP36878-4
English Herpes gestationis NOS, Herpes gestationis unspecified, herpes gestationis, herpes gestationis (diagnosis), Pemphigoid, Gestational, Pemphigoids, Gestational, Gestational Pemphigoid, Gestational Pemphigoids, Herpes gestationis, unspecified trimester, Pemphigoid Gestationis [Disease/Finding], pemphigoid gestationis, Herpes gestationnis, Gestational herpes, Herpes gestationis unspecified (disorder), Herpes gestationis NOS (disorder), Herpes gestationis, Dermatitis herpetiformis of pregnancy, Pemphigoid gestationis, Herpes gestationis (disorder), gestational; herpes, herpes; gestational, Herpes Gestationis, Gestationi, Pemphigoid, Pemphigoid Gestationi, Pemphigoid Gestationis, Gestationis, Pemphigoid
Italian Herpes gestazionis, Pemfigoide della gravidanza, Herpes gestazionale
Dutch pemfigoïd gestationis, gestationis; herpes, herpes; gestationis, herpes gestationis, Herpes gestationis
French Pemphigoïde gestationnelle, Herpès gestationis, Pemphigoïde gestationis, Herpes gestationis, Pemphigoïde gravidique
German Pemphigoid gestationis, Herpes gestationnis, Herpes gestationis
Portuguese Penfigóide gestacional, Penfigoide Gestacional, Herpes gestationis
Spanish Penfigoide gestacional, Herpes gestacional, herpes gestacional, SAI (trastorno), herpes gestacional, no especificado (trastorno), herpes gestacional, no especificado, herpes gestacional, SAI, dermatitis herpetiforme del embarazo (trastorno), dermatitis herpetiforme del embarazo, herpes gestacional (trastorno), herpes gestacional, Herpes del embarazo, Penfigoide Gestacional
Japanese 妊娠性類天疱瘡, ニンシンセイルイテンポウソウ, ニンシンヘルペス, 妊娠性疱疹, 妊娠性ヘルペス, 疱疹-妊娠性, ヘルペス-妊娠性, 妊娠ヘルペス, 妊娠疱疹
Swedish Pemphigoid gestationis
Czech pemphigoid gestationis, pemfigoid gestační, herpes gestationis, Gestační pemfigoid, Herpes v těhotenství, Herpes gestationis
Finnish Raskausrokahtuma
Russian PEMFIGOID BEREMENNYKH, GERPES BEREMENNYKH, ГЕРПЕС БЕРЕМЕННЫХ, ПЕМФИГОИД БЕРЕМЕННЫХ
Korean 임신 헤르페스
Polish Opryszczki ciężarnych
Hungarian Herpes gestationis, terhességi herpes, Pemphigoid, gestatios
Norwegian Herpes gestationis, Pemphigoid gestationis, Svangerskapspemfigoid