II. Indication

  1. Ventricular Arrhythmia
  2. Supraventricular Arrhythmia
    1. Atrial Fibrillation Cardioversion
      1. Time to Cardioversion: 3-6 hours
      2. Conversion Rate: 20-52%
      3. Chronic Efficacy: 50-60%

III. Mechanism

  1. Class III Antiarrhythmic
    1. Prolongs action potential duration
    2. Increases cardiac tissue refractoriness
  2. Class II Antiarrhythmic
    1. Non-selective Beta Blocker

IV. Adverse Effects

  1. Bradycardia
  2. Hypotension
  3. Proarrhythmia (Torsades de Pointes)
    1. Associated with doses over 320 mg per day

V. Dosing: Oral

  1. Starting Dose: 80 mg PO bid
  2. Typical dosing: 80-160 mg PO bid
  3. Maximum: 640 mg per day

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Cost: Medications

SOTALOL HCL (on 2/19/2015 at Target.com)
SOTALOL HCL 80 MG* Tablet #90 for $10.00 $0.11 each
sotalol (on 8/17/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
SOTALOL 120 MG TABLET Generic $0.14 each
SOTALOL 160 MG TABLET Generic $0.22 each
SOTALOL 80 MG TABLET Generic $0.09 each
SOTALOL AF 120 MG TABLET Generic $0.14 each
SOTALOL AF 160 MG TABLET Generic $0.22 each
SOTALOL AF 80 MG TABLET Generic $0.09 each

Ontology: Sotalol (C0037707)

Definition (NCI) An ethanolamine derivative with Class III antiarrhythmic and antihypertensive properties. Sotalol is a nonselective beta-adrenergic receptor and potassium channel antagonist. In the heart, this agent inhibits chronotropic and inotropic effects thereby slowing the heart rate and decreasing myocardial contractility. This agent also reduces sinus rate, slows conduction in the atria and in the atrioventricular (AV) node and increases the functional refractory period of the AV node.
Definition (MSH) An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D013015
SnomedCT 372911006, 96301002
LNC LP16279-9, MTHU003385
English Sotalol, Methanesulfonamide, N-(4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)phenyl)-, sotalol, Sotalol [Chemical/Ingredient], antiarrhythmics sotalol, sotalol (medication), SOTALOL, Sotalol (product), Sotalol (substance)
Swedish Sotalol
Czech sotalol
Finnish Sotaloli
Russian SOTALOL, СОТАЛОЛ
Japanese ソタロール
Polish Sotalol
Spanish sotalol (producto), sotalol (sustancia), sotalol, Sotalol
French Sotalol
German Sotalol
Italian Sotalolo
Portuguese Sotalol

Ontology: Betapace (C0728751)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Betapace, betapace