II. Indications

  1. Atrial Fibrillation Cardioversion
    1. Time to Cardioversion: 3-6h
    2. Conversion Rate: 38-86%
    3. Chronic Efficacy: 47-60%

III. Mechanism

  1. Class Ia Antiarrhythmic

IV. Dosing

  1. Dose: 324-648 mg PO q8h

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Cost: Medications

quinidine (on 5/18/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
QUINIDINE SULFATE 300 MG TAB Generic $0.20 each

Ontology: Quinidine (C0034414)

Definition (NCI) An alkaloid extracted from the bark of the Cinchona tree with class 1A antiarrhythmic and antimalarial effects. Quinidine stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting the sodium influx required for the initiation and conduction of impulses resulting in an increase of the threshold for excitation and decreased depolarization during phase 0 of the action potential. In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, resulting in decreased conduction velocity of nerve impulses. Quinidine exerts its antimalarial activity by acting primarily as an intra-erythrocytic schizonticide through association with the heme polymer (hemazoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme. This results in accumulation of toxic heme and death of the parasite.
Definition (MSH) An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
Definition (CSP) D isomer of quinine; sometimes used as an antimalarial in patients who cannot tolerate quinine.
Definition (PDQ) An alkaloid extracted from the bark of the Cinchona tree with class 1A antiarrhythmic and antimalarial effects. Quinidine stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting the sodium influx required for the initiation and conduction of impulses resulting in an increase of the threshold for excitation and decreased depolarization during phase 0 of the action potential. In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, resulting in decreased conduction velocity of nerve impulses. Quinidine exerts its antimalarial activity by acting primarily as an intra-erythrocytic schizonticide through association with the heme polymer (hemazoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme. This results in accumulation of toxic heme and death of the parasite. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39022&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39022&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C793" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D011802
SnomedCT 31306009, 372697008
LNC LP16271-6, MTHU005039
English Chinidin, Quinidine, Cinchonan-9-ol, 6'-methoxy-, (9S)-, quinidine (medication), Quinidine [Chemical/Ingredient], quiNIDine, quinidine, QUINIDINE, Quinidine (product), Quinidine (substance)
Swedish Kinidin
Czech chinidin
Finnish Kinidiini
Russian KHINIDIN, ХИНИДИН
Japanese 硫酸キニジン, キニジン
Croatian KINIDIN
Polish Chinidyna
Spanish quinidina (producto), quinidina (sustancia), quinidina, Quinidina
French Quinidine
German Chinidin
Italian Chinidina
Portuguese Quinidina

Ontology: Quinaglute (C1097294)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C016713
English Quinaglute, quinaglute, Berlex brand of quinidine gluconate