II. Preparations

  1. Potassium-Sparing Diuretics only
    1. Amiloride (Midamor)
    2. Triamterene (Dyrenium)
  2. Potassium-Sparing Diuretic and Aldosterone Antagonists
    1. Spironolactone (Aldactone)
    2. Eplerenone (Inspra)

III. Precautions

  1. Monitor Serum Potassium after starting a Potassium-Sparing Diuretic in those at Hyperkalemia risk
    1. Obtain Serum Potassium at 3 days, 7 days and then monthly for the first 3 months

IV. Drug Interactions

  1. Potassium supplements (risk of Hyperkalemia)
  2. CYP3A4 Inhibitors (Eplerenone only)
    1. Significantly increases Eplerenone levels

Images: Related links to external sites (from Bing)

Related Studies (from Trip Database) Open in New Window

Cost: Medications

TRIAMTERENE/HCTZ (on 2/19/2015 at Target.com)
TRIAMTERENE/HCTZ 75/50 MG Tablet #90 for $10.00 $0.11 each
amiloride (on 8/17/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
AMILORIDE HCL 5 MG TABLET Generic $0.49 each
AMILORIDE HCL-HYDROCHLOROTHIAZIDE 5-50 MG TAB Generic $0.37 each
triamterene (on 8/17/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
TRIAMTERENE-HYDROCHLOROTHIAZIDE 37.5-25 MG CP Generic $0.19 each
TRIAMTERENE-HYDROCHLOROTHIAZIDE 37.5-25 MG TB Generic $0.13 each
TRIAMTERENE-HYDROCHLOROTHIAZIDE 50-25 MG CAP Generic $1.53 each
TRIAMTERENE-HYDROCHLOROTHIAZIDE 75-50 MG TAB Generic $0.14 each

Ontology: Amiloride (C0002502)

Definition (NCI) A synthetic pyrazine derivative with antikaliuretic and diuretic properties. Amiloride inhibits sodium channels located in the distal tubules and collecting ducts of the kidney, thereby preventing the absorption of sodium and increasing its excretion along with water, to produce naturesis. In response to the hypernatremic conditions in the kidney, the plasma membrane becomes hyperpolarized and electrochemical forces are reduced, which then prevents the excretion of potassium and hydrogen into the lumen.
Definition (CSP) pyrazine compound inhibiting sodium reabsorbtion through sodium channels in renal epithelial cells; used in conjunction with diuretics to spare potassium loss.
Definition (MSH) A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D000584
SnomedCT 387503008, 87395005
LNC LP16024-9, MTHU006775
English Amiloride, Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, Amiloride [Chemical/Ingredient], aMILoride, AMILORIDE, amiloride, Amipramizide, Amiloride (product), Amiloride (substance)
Swedish Amilorid
Czech amilorid
Finnish Amiloridi
Russian AMILORID, АМИЛОРИД
Croatian AMILORID
Polish Amiloryd
Japanese アミロライド, アミパミジン, アミロラジド, アミロリド
Spanish amilorida (producto), amilorida (sustancia), amilorida, Amilorida
French Amiloride
German Amilorid
Italian Amiloride
Portuguese Amilorida

Ontology: Midamor (C0026054)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D000584
English midamor, Cahill May Roberts Brand of Amiloride Hydrochloride, Merck Brand of Amiloride Hydrochloride, Merck Sharp & Dohme Brand of Amiloride Hydrochloride, Modamide, Midamor

Ontology: Triamterene (C0040869)

Definition (MSH) A pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.
Definition (NCI) A pteridine derivative with potassium-sparing diuretic property. Triamterene blocks the sodium-potassium exchange pump (Na-K-ATPase) in the luminal membrane of principal cells in the late distal tubule, cortical collecting tubule and collecting duct in the kidney. This reversible inhibition of the electrogenic sodium transport decreases the lumen-negative transepithelial potential difference and thus reduces the driving force for K+ movement into the tubular lumen resulting in the inhibition of sodium reabsorption in exchange for K+ and H+.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D014223
SnomedCT 12512008, 387053007
LNC LP14734-5, MTHU001919
English Triamterene, 2,4,7-Pteridinetriamine, 6-phenyl-, triamterene, triamterene (medication), TRIAMTERENE, Triamterene [Chemical/Ingredient], 6-Phenyl-2,4,7-triaminopteridine, 6-Phenyl-2,4,7-pteridinetriamine, Triamterene (product), Triamterene (substance)
Swedish Triamteren
Czech triamteren
Finnish Triamtereeni
Russian TRIAMTEREN, PTEROFEN, ПТЕРОФЕН, ТРИАМТЕРЕН
Japanese トリアムテレン
Polish Triamteren
Spanish triamtereno (producto), triamtereno (sustancia), triamtereno, Triantereno
French Triamtérène
German Triamteren
Italian Triamterene
Portuguese Triantereno

Ontology: Dyrenium (C0700653)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D014223
English Dyrenium, Wellspring Brand of Triamterene