II. Physiology

  1. Transferase class enzyme activated by Magnesium
  2. Catalyzes ATP energy storage as phosphocreatine
  3. Phosphocreatine stored in muscle and brain
  4. Phosphocreatine keeps ATP constant at Exercise start

IV. Isoenzymes:

  1. MB: Heart
  2. MM: Skeletal muscle
  3. BB:
    1. Brain
    2. Bowel infarction
    3. Neoplasm (Prostate, GI, Breast, Ovary, Lung, Brain)

V. Protocol: Acute Coronary Syndrome Evaluation

  1. Older protocol - replaced in United States with Troponin
  2. Obtain Serial CPK every 6 hours for total of 3 values
  3. Fractionate to CK-MB only if CPK increased
  4. CK-MB >5% of total CPK suggests Myocardial Infarction

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Ontology: Creatine Kinase (C0010287)

Definition (NCI) An enzyme complex that can reversibly convert ATP and creatine to phosphocreatine and ADP. Cytosolic creatine kinases are comprised of homodimers or heterodimers of creatine kinase B-type protein and creatine kinase M-type protein. Mitochondrial creatine kinases are octomers comprised of either four homodimers of creatine kinase U-type, mitochondrial protein or four creatine kinase S-type, mitochondrial protein homodimers.
Definition (MSH) A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
Concepts Amino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSH D003402
SnomedCT 75828004
LNC LP15510-8, MTHU006937
English ADP Phosphocreatine Phosphotransferase, ATP Creatine Phosphotransferase, Creatine Kinase, Creatine Phosphokinase, Creatine Phosphotransferase, ATP, Kinase, Creatine, Phosphocreatine Phosphotransferase, ADP, Phosphokinase, Creatine, Phosphotransferase, ADP Phosphocreatine, Phosphotransferase, ATP Creatine, creatine kinase, ATP:creatine N-phosphotransferase, Creatine Kinase [Chemical/Ingredient], creatine kinase (CK), creatine phosphokinase (CPK), creatine phosphokinase, Phosphocreatine Kinase, ATP:Creatine N-Phosphotransferase, Creatine Phosphotransferase, CPK, CK, Adenosine Triphosphate-Creatine Transphosphorylase, ATP:Creatine Phosphotransferase, Creatine kinase, Creatine phosphokinase, CK - Creatine kinase, CPK - Creatine phosphokinase, Creatine kinase (substance)
Swedish Kreatinkinas
Czech kreatinfosfokinasa, kreatinkináza, kreatinkinasa
Finnish Kreatiinikinaasi
Russian KREATINFOSFOKINAZA, KREATINKINAZA, IZOFERMENTY KREATINKINAZY, KREATINKINAZY IZOFERMENTY, ИЗОФЕРМЕНТЫ КРЕАТИНКИНАЗЫ, КРЕАТИНКИНАЗА, КРЕАТИНКИНАЗЫ ИЗОФЕРМЕНТЫ, КРЕАТИНФОСФОКИНАЗА
Japanese クレアチンキナーゼ, クレアチンホスホキナーゼ, ローマン酵素
Italian ADP fosfocreatina fosfotransferasi, ATP creatina fosfotransferasi, Creatina fosfochinasi, Creatinchinasi
Croatian KREATIN KINAZA
Polish Fosfokinaza kreatynowa, Kinaza fosfokreatynowa, Kinaza kreatynowa
Portuguese Creatinoquinase, Creatina Fosfoquinase, Creatina Quinase
Spanish creatina cinasa (sustancia), creatina cinasa, creatina fosfocinasa, creatincinasa, creatinquinasa, Creatina Fosfoquinasa, Creatina Quinasa
French CPK, Creatine kinase, ATP créatine N-phosphotransférase, Créatine phosphokinase
German Creatin-Kinase, Creatinkinase-Isoenzyme, Creatinkinase-Isozyme, Creatinphosphokinase, Kreatinase-Isoenzyme, Kreatinase-Isozyme, Kreatinase, Kreatinphosphokinase, Creatinkinase, Kreatinkinase, Kreatinkinase-Isoenzyme

Ontology: PIK3C2A gene (C1418571)

Concepts Gene or Genome (T028)
English C2-CONTAINING PHOSPHATIDYLINOSITOL KINASE, PIK3C2A, PHOSPHATIDYLINOSITOL 3-KINASE, CLASS 2, ALPHA, CPK, PI3K-C2alpha, phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha, PIK3C2A gene