II. Epidemiology

  1. Incidence (U.S.)
    1. Outpatient: 4.6% (based on presenting Blood Pressure)
      1. Still uncontrolled in >60% of patients after 6 months (esp. due to noncompliance)
      2. Patel (2016) JAMA Intern Med 167(7): 981-88 [PubMed]
    2. Emergency Department: 4% are diagnosed with Severe Asymptomatic Hypertension
      1. McNaughton (2015) Am J Cardiol 116(11): 1717-23 [PubMed]
    3. Inpatients: 4.5% receive Intravenous Antihypertensives
      1. Weder (2010) J Clin Hypertens 12(1): 29-33 [PubMed]

IV. Symptoms

  1. Although termed "asymptomatic", mild symptoms may be present
    1. Contrast with the acute target organ injury symptoms related to Hypertensive Emergency or urgency
    2. See Severe Hypertension for Acute Severe Hypertension-Related Target Organ Injury Findings
  2. Mild symptoms
    1. Headache
    2. Light Headedness
    3. Nausea
    4. Dyspnea
    5. Palpitations
    6. Epistaxis
    7. Anxiousness
  3. Severe Symptoms or Target Organ Injury Symptoms
    1. See Hypertensive Emergency
    2. Red flag symptoms that suggest possible Hypertensive Emergency

VI. Diagnosis: Severe Uncontrolled Hypertension (Severe Asymptomatic Hypertension)

  1. Severe Hypertension (SBP>180, DBP>110) AND
  2. Asymptomatic patient with no signs of end-organ dysfunction
    1. No criteria met for Hypertensive Emergency or Hypertensive Urgency (see differential diagnosis below)

VII. Differential Diagnosis

  1. See Resistant Hypertension
  2. See Secondary Hypertension Causes
  3. See Severe Hypertension
  4. Hypertensive Emergency (Hypertensive Crisis)
    1. Rapid and progressive decompensation of vital organ function secondary to severely elevated Blood Pressure
    2. Acute life-threatening complications due to Severe Hypertension (acute Myocardial Infarction, Hemorrhagic CVA)
  5. Hypertensive Urgency
    1. Progressive end-organ damage risk factors (pre-existing CHF, Unstable Angina, Chronic Kidney Disease)
    2. Unlike Hypertensive Emergency there is no evidence of new injury secondary to Severe Hypertension

VIII. Labs

  1. See Hypertension Evaluation Labs
  2. Diagnostics are rarely needed in Severe Asymptomatic Hypertension
    1. Caveats
      1. Significant symptoms should prompt full Hypertensive Emergency evaluation and management
      2. May consider diagnostics for specific mild symptoms possibly due to Severe Hypertension
    2. ACEP does not recommend routine diagnostic testing in Severe Asymptomatic Hypertension
      1. Wolf (2013) Ann Emerg Med 62(1): 59-68 [PubMed]
    3. Diagnostic testing is abnormal in <5% of Severe Asymptomatic Hypertension
      1. Patel (2016) JAMA Intern Med 176(7): 981-88 [PubMed]

IX. Evaluation

X. Management

  1. Precautions
    1. Exclude Hypertensive Emergency and Hypertensive Urgency
      1. Based on history and exam (see evaluation above)
      2. See Hypertensive Emergency for complete evaluation and management
    2. Severe Asymptomatic Hypertension Inpatient management indications (rare)
      1. for escalating Hypertension, progressive symptoms
    3. Avoid aggressively lowering Blood Pressure
      1. See Severe Hypertension for risk of adverse events with rapid Blood Pressure lowering
  2. Start oral antihypertensive (or restart, adjust anti-hypertensives patient is already taking)
    1. See Antihypertensive Selection
    2. See Hypertension Management for Specific Comorbid Diseases
    3. See Hypertension Management for Specific Populations
    4. Medications with activity onset over hours (but less ideal for longterm tolerance)
      1. Labetalol 100 mg orally twice daily
      2. Clonidine 0.1 to 0.2 mg orally twice daily
      3. Prazosin 1-2 mg orally twice daily
      4. Diltiazem 30 mg orally four times daily
      5. Captopril 25 mg orally two to three times daily
    5. Medications with activity onset over days (but better for longterm use)
      1. Lisinopril 10 mg orally once daily (recheck Serum Creatinine, Potassium in 10 days)
      2. Losartan 50 mg orally once daily (recheck Serum Creatinine, Potassium in 10 days)
      3. Metoprolol Succinate 25-50 mg orally daily
      4. Amlodipine 2.5 to 5 mg orally once daily
      5. Hydrochlorothiazide 12.5 to 25 mg orally once daily
  3. Follow-up 1 week
    1. May delay follow-up to 2-4 weeks if no symptoms and adjusting medications in established Hypertension

XI. Prognosis

  1. Shortterm serious adverse effects of Severe Asymptomatic Hypertension are rare (even over months of follow-up)
    1. Outpatient management (from the clinic) is safe and effective
    2. Emergency management, diagnostics, Intravenous Antihypertensives are not needed in asymptomatic patients
    3. Nakprasert (2016) Am J Emerg Med 34(5): 834-9 [PubMed]
    4. Patel (2016) JAMA Intern Med 167(7): 981-88 [PubMed]
  2. Longterm serious adverse effects of Hypertension are well established
    1. See Hypertension
    2. Appropriate consistent chronic management is important

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