Urology Book

http://www.fpnotebook.com/

Pentosan polysulfateAka: Elmiron

Advertisement

  1. Indications
    1. Interstitial Cystitis
  2. Mechanism
    1. Semisynthetic glucosaminoglycan
  3. Dosing
    1. Pentosan Polysulfate 100 mg PO tid
  4. Efficacy
    1. Symptoms improve as much as 50% in controlled trials
    2. Response may not be seen for 3 to 6 months
  5. Adverse Effects
    1. Diarrhea
    2. Dyspepsia
    3. Alopecia (reversible)
    4. Headache
    5. Rash
    6. Dizziness
    7. Abdominal Pain
    8. Liver function abnormalities (<4%)
  6. References
    1. Bade (1997) Br J Urol 79:168-71
    2. Parsons (1993) J Urol 150:845-8

Elmiron (C0600293)

ConceptsCarbohydrate (T118) , Pharmacologic Substance (T121)
EnglishElmiron
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Pentosan Polysulfate (C0600296)

Definition (NCI)A drug used to relieve pain or discomfort associated with chronic inflammation of the bladder. It is also being evaluated for its protective effects on the gastrointestinal tract in people undergoing radiation therapy.
Definition (NCI)A semisynthetic heparin-like glucosaminoglycan. Although its mechanism of action is unknown, pentosan polysulfate may act as a buffer to control cell permeability by preventing irritating solutes from reaching cells coated with it. Administered orally, excreted pentosan polysulfate adheres to the urinary bladder wall, preventing irritants from entering bladder cells and the development or progression of interstitial cystitis (IC), a complication of some chemotherapies. This agent also exhibits anticoagulant and fibrinolytic properties. (NCI04)
ConceptsCarbohydrate (T118) , Pharmacologic Substance (T121)
EnglishPentosan Polysulfate, Pentosan polysulphate, Xylan Hydrogen Sulfate, Xylan Polysulfate
Spanishpolisulfato de pentosan, polisulfato de pentosano
CreditsDerived from the NIH UMLS (Unified Medical Language System)



Navigation Tree