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Intraurethral AlprostadilAka: MUSE

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  1. Indications
    1. Psychogenic Impotence
    2. Neurogenic Impotence
    3. Vasculogenic Impotence
  2. Contraindications
    1. Penile deformity (e.g Peyronie's Disease)
    2. Sexual intercourse with pregnant women
      1. Risk of Preterm Labor
    3. Priapism risk
      1. Sickle Cell Disease or Sickle Cell Trait
      2. Leukemia
      3. Multiple Myeloma
      4. Polycythemia Vera
      5. Thrombocythemia
  3. Preparation
    1. Transurethral preparation
      1. Inserted 3 cm into urethra with plastic applicator
    2. Semi-solid pellet
      1. Diameter: 1.4 mm
      2. Length: 3-6 mm
  4. Efficacy
    1. Successful intercourse in 65% of 1511 tested
    2. Placebo success rate: 19%
  5. Adverse effects
    1. Hypotension (3%)
    2. Dizziness (2%)
    3. Mild Erectile discomfort (32%)
    4. Minor Urethral burning or bleeding
    5. Priapism is rare
  6. Dosing
    1. Dose 125-1000 ug ($114-$137 for 6 units)
  7. Reference
    1. Padma-Nathan (1997) N Engl J Med 336(1):1

Prostin VR (C0592016)

ConceptsEicosanoid (T111) , Pharmacologic Substance (T121)
MSHD000527
EnglishAbbott Brand of Alprostadil, Astra Brand of Alprostadil, AstraZeneca Brand of Alprostadil, Janssen Brand of Alprostadil, Minprog, Muse, Paladin Brand of Alprostadil, Pharmacia Brand 1 of Alprostadil, Prostin VR, Prostine VR, Vivus Brand of Alprostadil
SourcesMSH, MTH, NCI, PDQ, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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