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ApomorphineAka: Uprima

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  1. Mechanism
    1. Central acting, Dopaminergic agonist
  2. Pharmacokinetics
    1. Onset: 10 minutes
    2. Duration: 30 minutes
  3. Dose
    1. Uprima 2 to 6 mg SL
  4. Efficacy
    1. Effective in 55 to 60% of men (contrast 32% in Placebo)
  5. Adverse Effects (58% of men on 6 mg)
    1. Nausea (39%)
    2. Vomiting (10%)
    3. Dizziness (20%)
    4. Somnolence (11%)
    5. Sweaty (18%)
    6. Hypotension (4%)
    7. Syncope (2%)

Apomorphine (C0003596)

Definition (MSH)A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.
Definition (CSP)derivative of morphine that is a dopamine D2 agonist; a powerful emetic useful in acute poisoning; has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD001058
EnglishApomorphine, APOMORPHINE PREPARATION
Spanishapomorfina
Parent ConceptsAporphines (C0003606), Antiparkinson Agents (C0003405), Emetics (C0013973), Morphine (C0026549), Dopamine Agonists (C0178601), Unclassified Ingredient Preparations (C1377282)
SourcesAOD, CSP, LCH, MSH, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Uprima (C1657321)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishUprima
SourcesNCI
Derived from the NIH UMLS (Unified Medical Language System)



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