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Peyronie's DiseaseAka: Peyronie's Syndrome, Plastic Induration of the penis, Induratio Penis Plastica, Strabismus Penis

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  1. Epidemiology
    1. Males aged 45 to 65 years old
  2. History
    1. Named for Italian physician to King Louis XIV of France
  3. Pathophysiology
    1. Diminished elasticity of collagen of penis
    2. Irregular fibrosis of the corpora cavernosa of penis
      1. Fibrosis of septum or sheath
      2. Extends into tunica albuginea
    3. Spares corpus cavernosum urethra
  4. Associated Conditions: Dupuytren's Contracture (47%)
    1. Palmar Fibrosis
    2. Plantar Fibrosis
  5. Differential Diagnosis
    1. Tertiary Syphilis Gumma
    2. Scleroderma
    3. Alcohol Abuse
    4. Diabetes Mellitus
    5. Local trauma
    6. Gouty Tophi
  6. Symptoms
    1. Focal pain with Erection (50 to 66%)
      1. Pain resolves as inflammation subsides
    2. Lateral curvature of the penis during Erection
    3. Penis flail distal to lesion
  7. Signs
    1. Firm, nontender Plaques
    2. Location
      1. Lateral corpora cavernosa
      2. Dorsal over intercorporeal septum
  8. Course
    1. Penile Plaque forms, scars and remodels over first year
    2. Spontaneous resolution in 20 to 50% of younger men
    3. Scarring progresses to calcification in 25% of men
    4. Calcification progresses to bone in 25% of men
  9. Management: Non-surgical
    1. Vitamin E 100 mg PO tid for over 4 months
      1. Evidence suggests no better than Placebo
    2. Verapamil intralesional injection
    3. Potassium Aminobenzoate 2 g PO 6x/day for 6-12 months
    4. Corticosteroid intralesional injection
      1. Use small gauge needle with no anesthetic
      2. Most effective if used early in Peyronie's Disease
      3. Decadron 0.2-0.4 mg per Plaque weekly for 10 weeks
      4. Aristospan 2 mg per Plaque every 6 weeks for 36 weeks
    5. Avoid intercourse during treatment to avoid trauma
  10. Management: Surgical
    1. Nesbit Procedure
      1. Plaque excision with patch grafting of defect
  11. References
    1. Degowin (1987) Diagnostic Exam, Macmillan, p. 606-7
    2. Fitkin (1999) Am Fam Physician 60(2):549

Peyronie Disease (C0030848)

Definition (MSH)A condition characterized by hardening of the PENIS due to the formation of fibrous plaques on the dorsolateral aspect of the PENIS, usually involving the membrane (tunica albuginea) surrounding the erectile tissue (corpus cavernosum penis). This may eventually cause a painful deformity of the shaft or constriction of the urethra, or both.
Definition (NCI)A superficial fibromatosis arising from the soft tissues of the penis. It is characterized by the presence of spindle-shaped fibroblasts, and an infiltrative growth pattern.
ConceptsDisease or Syndrome (T047)
ICD9607.81, 607.85
MSHD010411
EnglishFibrous Cavernitides, Fibrous Cavernitis, Fibrous cavernositis, Induratio penis plastica, Penile Fibromatosis, Penile Induration, PEYRONIE DIS, Peyronie Disease, Peyronie's Disease, Peyronie's Fibromatosis, PEYRONIE'S SYNDROME, PEYRONIES DIS, PEYRONIES DISEASE, Plastic induration of penis, Plastic Induration of the Penis
Spanishcavernositis fibrosa, enfermedad de Peyronie, fibromatosis peniana, induracion plastica del pene
Parent Concepts[X]Other specified disorders of penis (C0029785), Connective Tissue Diseases (C0009782), Penile Diseases (C0030846), Superficial fibromatosis (C0406571), Deformity of erection (C0549144), Duplicate concept (C1274013)
SourcesCOSTAR, CST, DXP, ICD9CM, LCH, MSH, MTH, MTHICD9, NCI, NDFRT, OMIM, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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