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Urine Protein to Creatinine RatioAka: Urine Albumin to Creatinine Ratio

Indication
1. Monitor persistant Proteinuria
Efficacy
1. More accurate than 24 Hour Urine Protein collection
2. Most accurate if first morning void is used
Technique: Random urine collection
1. Urine Creatinine in mg
2. Urine Protein in mg
3. Calculate Urine Protein mg to Urine Creatinine mg Ratio
Interpretation of Urine Protein to Urine Creatinine Ratio
1. Child under age 2 years
  1. Normal Ratio <0.5
2. Adults and children over age 2 years
  1. Normal ratio <0.2 grams protein per gram Creatinine
    1. Correlates with 0.2 g protein/day
  2. Nephrotic Ratio >3.5 (correlates with 3.5 g protein)
Interpretation of Urine Albumin to Creatinine Ratio
1. Normal Ratio (in general <30 mg/g is normal)
  1. Men: < 0.017 (or 17 mg albumin to 1 gram Creatinine)
  2. Women: <0.025 (or 25 mg albumin to 1 gram Creatinine)
2. Microalbuminuria: 30-300 mg albumin/g Creatinine
3. Macroalbuminuria: >300 mg albumin/g Creatinine
References
1. Ruggenenti (1998) BMJ 316:504
2. (2002) Am J Kidney Dis 39:S1

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 5/10/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.