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Bile Acid Oral Dissolution TherapyAka: Ursodeoxycholic Acid, Ursodiol, Actigal, Oral Dissolution Therapy

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  1. Indication: Cholelithiasis
    1. Comorbid condition that precludes safe Cholecystectomy
    2. Symptomatic patient unwilling to undergo surgery
  2. Inclusion Criteria required (only 15% of patients)
    1. Small, floating, Cholesterol Gallstones (<0.5mm)
    2. Functional Gallbladder
  3. Treatment Protocol: Ursodiol (Actigal)
    1. Dose: 8-10 mg/kg/day PO divided bid to tid
    2. Course: 6-12 months
  4. Efficacy
    1. Stones dissolving over 6-12 months: 60-90%
    2. Stones reoccuring within 5 years: 25-50%
    3. Better prognosis associated factors
      1. Single Gallstone and
      2. non-obese and
      3. Young patient

Ursodiol (C0042105)

Definition (MSH)An epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic.
Definition (PDQ)A synthetically-derived form of ursodiol, a bile acid produced by the liver and secreted and stored in the gallbladder. Also produced by the Chinese black bear liver, ursodiol has been used in the treatment of liver disease for centuries. This agent dissolves or prevents cholesterol gallstones by blocking hepatic cholesterol production and decreasing bile cholesterol. Ursodiol also reduces the absorption of cholesterol from the intestinal tract. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=306453&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=306453&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1818" NCI Thesaurus)
Definition (NCI)A synthetically-derived form of ursodiol, a bile acid produced by the liver and secreted and stored in the gallbladder. Also produced by the Chinese black bear liver, ursodiol has been used in the treatment of liver disease for centuries. This agent dissolves or prevents cholesterol gallstones by blocking hepatic cholesterol production and decreasing bile cholesterol. Ursodiol also reduces the absorption of cholesterol from the intestinal tract.
ConceptsSteroid (T110) , Pharmacologic Substance (T121) , Biologically Active Substance (T123)
EnglishDeoxyursocholic Acid, UDCA, Ursacholic Acid, Ursodeoxycholic Acid, Ursodeoxycholic acid product, Ursodesoxycholic acid, Ursodiol, URSODIOL PREPARATION
Spanishácido urodesoxicólico, ácido ursodesoxicólico, acido urodesoxicolico, acido ursodesoxicolico, ursodiol
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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