II. Techniques

  1. Blood Doping (Blood Boosting)
    1. pRBC Units donated well before an event
    2. pRBC transfused immediately before an event
  2. Recombinent Erythropoietin (rEPO)
    1. Stimulates red cell mass
    2. Very expensive
    3. Same effect as Blood Doping

III. Adverse Effects

  1. Hypercoagulation risk may be fatal
    1. Deep Vein Thrombosis
    2. Pulmonary Embolism
    3. Cerebrovascular Accident
    4. Myocardial Infarction
    5. Eighteen deaths by European Cyclists who blood doped
  2. Transfusion reaction
  3. Bloodbourne infection (including HIV)

IV. Efficacy

  1. Increases performance in endurance sports (e.g. long-distance cycling)

V. Detection

  1. Not detected, but banned by olympic committee 1984

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Ontology: Recombinant Erythropoietin (C0376541)

Definition (NCI) A recombinant therapeutic agent which is chemically identical to or similar to the endogenous glycoprotein erythropoietin (Epo). Epo promotes the differentiation and maturation of hematopoietic progenitors into erythrocytes; is a mitogen and a chemoattractant for endothelial cells; stimulates activated and differentiated B-cells and enhances B-cell immunoglobulin production and proliferation; and is hypoxia-inducible. (NCI04)
Concepts Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116)
MSH D019321
Swedish Erytropoietin, rekombinant
Finnish Yhdistelmä-erytropoietiini
Japanese エリスロポエチン-組換え, 組換えエリトロポイエチン, 組換えエリスロポエチン
English erythropoietin recombinant, recombinant erythropoietin, ERYTHROPOIETIN, r-HuEPO, Erythropoietin, Erythrocyte Colony Stimulating Factor, Hematopoietin, Recombinant EPO, Recombinant Erythropoietin