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Blood DopingAka: Blood Boosting

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  1. Techniques
    1. Blood doping (blood boosting)
      1. pRBC Units donated well before an event
      2. pRBC transfused immediately before an event
    2. Recombinent Erythropoietin (rEPO)
      1. Stimulates red cell mass
      2. Very expensive
      3. Same effect as blood doping
  2. Adverse Effects
    1. Hypercoagulation risk may be fatal
      1. Deep Vein Thrombosis
      2. Pulmonary Embolism
      3. Cerebrovascular Accident
      4. Myocardial Infarction
      5. Eighteen deaths by European Cyclists who blood doped
    2. Transfusion reaction
    3. Bloodbourne infection (including HIV)
  3. Efficacy
    1. Increases performance in endurance sports (e.g. long-distance cycling)
  4. Detection
    1. Not detected, but banned by olympic committee 1984

Recombinant Erythropoietin (C0376541)

Definition (MSH)ERYTHROPOIETIN prepared by recombinant DNA technology.
Definition (NCI)A recombinant therapeutic agent which is chemically identical to or similar to the endogenous glycoprotein erythropoietin (Epo). Epo promotes the differentiation and maturation of hematopoietic progenitors into erythrocytes; is a mitogen and a chemoattractant for endothelial cells; stimulates activated and differentiated B-cells and enhances B-cell immunoglobulin production and proliferation; and is hypoxia-inducible. (NCI04)
ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
MSHD019321
EnglishErythrocyte Colony Stimulating Factor, Erythropoietin, Hematopoietin, r-HuEPO, Recombinant EPO, Recombinant Erythropoietin
Parent ConceptsErythropoietin (C0014822), Recombinant Proteins (C0034861), Miscellaneous Chemoprotective Agent (C1513327), Recombinant Hematopoietic Growth Factor (C1515378)
SourcesMSH, MTH, NCI, NDFRT, PDQ
Derived from the NIH UMLS (Unified Medical Language System)



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