Rheumatology Book

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TeriparatideAka: Forteo

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  1. Mechanism
    1. Recombinant Parathyroid Hormone
  2. Indications
    1. Osteoporosis (high risk men and postmenopausal women)
  3. Dose: 20 mcg SQ qd
  4. Efficacy
    1. BMD increases 5.9% at spine and 1.5% at femoral neck
    2. Reduced risk for osteoporotic Fractures
      1. Neer (2001) N Engl J Med 344:1434
  5. Contraindications
    1. Hyperparathyroidism
    2. Paget's Disease
    3. Osteomalacia
    4. End Stage Renal Disease
    5. Bone cancer
    6. Active Nephrolithiasis
    7. Hypercalcemia
  6. Precautions
    1. Do not use with bisphosphonate
    2. Use limited to 2 year maximum
  7. Resources
    1. National Osteoporosis Foundation Clinicians Guide To Osteoporosis
      1. http://www.nof.org/professionals/Clinicians_Guide.htm
  8. References
    1. Campion (2003) Am Fam Physician 67(7):1521
    2. Orwoll (2003) J Bone Miner Res 18:9

Teriparatide (C0070093)

Definition (MSH)A polypeptide that consists of the 1-34 amino-acid fragment of human PARATHYROID HORMONE, the biologically active N-terminal region. The acetate form is given by intravenous infusion in the differential diagnosis of HYPOPARATHYROIDISM and PSEUDOHYPOPARATHYROIDISM. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
MSHD019379
EnglishHPTH 001 034, Teriparatide, TERIPARATIDE @ @ UNIDENTIFIED, TERIPARATIDE PREPARATION, TERIPARATIDE UNIDENTIFIED
Spanishteriparatida, teriparatide
Parent ConceptsParathyroid Hormones (C0030520), Recombinant Growth Factor (C1515377), Parathyroid gland (C0030518), [DX900] DIAGNOSTICS, OTHER (C0973537), Unclassified Ingredients (C1372954), Diagnostic agents (C0358514), Polypeptides (C1305923), Calcium regulating hormone (C0360589)
SourcesMSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Forteo (C1170286)

ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121)
MSHD019379
EnglishForteo, Lilly Brand of Teriparatide, Teriparatide Lilly Brand
SourcesMSH, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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