Rheumatology Book

http://www.fpnotebook.com/

CyclobenzaprineAka: Flexeril

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  1. Class
    1. Antispasmodic Skeletal Muscle Relaxant
  2. Dosing
    1. Start: 5 mg orally at bedtime (5 mg is as effective as 10 mg and with less Sedation)
    2. Maximum: 10 mg orally three times daily
  3. Contraindications
    1. Older patients
      1. See Medications to Avoid in Older Adults
    2. Seizure disorder (if concurrently on Tramadol)
    3. Glaucoma
    4. Cardiac arrhythmia
    5. Congestive Heart Failure
    6. Recent Myocardial Infarction
  4. Adverse effects
    1. Common: Anticholinergic
      1. Drowsiness
      2. Dry Mouth
      3. Urinary Retention
      4. Increased Intraocular Pressure
    2. Rare
      1. Arrhythmia
      2. Seizure
      3. Myocardial Infarction
  5. References
    1. Borenstein (2003) Clin Ther 25(4):1056
    2. Browning (2001) Arch Intern Med 161:1613
    3. Tofferi (2004) Arthritis Rheum 51:9

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