http://www.fpnotebook.com/

Major Histocompatibility Complex AntigensAka: Human Leukocyte Antigen B27, HLA-B27

Indications
1. Extremely limited use in clinical practice
2. May be indicated if spondylitis strongly suspected
Methods of Testing
1. Antibody binding to patient's cells
2. Mixed Lymphocyte responses against specific targets
3. Hybridization to DNA probes
Efficacy
1. Test Sensitivity for Spondyloarthropathy: 84%
2. Test Specificity for Spondyloarthropathy: 96%
Conditions associated with HLA-B27 (with Incidence)
1. Ankylosing Spondylitis: 95%
2. Reiter's Syndrome: 80%
3. Spondylitis with Psoriasis: 70%
4. Spondylitis with Inflammatory Bowel Disease: 50%
5. Incidence in general population without disease: 6-8%
References
1. Gregersen in Ruddy (2001) Kelly's Rheumatology, p. 101
2. Lane (2002) Am Fam Physician 65(6):1073-80

Navigation Tree

Please see the Terms and Conditions. Please also see the privacy statement regarding advertising on this page. Although access to this page is not restricted, the information found here is intended for use by medical providers. Patients should address specific medical concerns with their physicians.

This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 6/1/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.